Volume 39 Issue 2, February 2021

How pain receptors drive inflammation

Colorized scanning electron micrograph of silicone-encapsulated gold interconnects of a device for epineural optogenetic neuromodulation. Michoud et al. use the device to show how nociceptor activation drives protective pain behavior and inflammation.

See Michoud et al.

Image: Frédéric Michoud. Cover Design: Erin Dewalt.

Editorial

Cleaning house

With drug pricing a priority for the US Biden administration, the biotech industry must clean up its act: stop profiteering from old products and stamp out anticompetitive practices.

Editorial 01 Feb 2021

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News

Drug startups coalesce around condensates

Once a neglected biological phenomenon, condensates are attracting interest from small companies and large pharmas.

Elie Dolgin
News 09 Feb 2021
Dendritic cell revival

News in Brief 09 Feb 2021
Atalanta pioneers siRNA for neurodegenerative diseases

News in Brief 09 Feb 2021
Light-activated genetic therapy to treat blindness enters clinic

Novartis is betting that optogenetics, a technology used by researchers to control cell signaling, is ready for the clinic.

Mark Ratner
News 09 Feb 2021
Diabetes drug on trial for Alzheimer’s

News in Brief 09 Feb 2021
Trop2 deal heats up antibody–drug conjugate space in cancer

Gilead’s $21 billion gamble is a dramatic shot to secure a promising first-in-class oncology drug.

Catherine Shaffer
News 09 Feb 2021
Around the world in a month

News in Brief 09 Feb 2021
Data Page
- Drug pipeline 4Q20
  
  Laura DeFrancesco
  Data Page 09 Feb 2021
- Financing breaks all records in 2020
  
  Laura DeFrancesco
  Data Page 09 Feb 2021
News Feature
- Refreshing the biologic pipeline 2020
  
  In the absence of face-to-face meetings, FDA and industry implemented regulatory workarounds to maintain drug and biologics approvals. These could be here to stay.
  
  John Hodgson
  News Feature 28 Jan 2021

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Correspondence

Research priorities for COVID-19 sensor technology

Allison Tong
Tania C. Sorrell
Hans Zoellner
Correspondence 18 Jan 2021
Will Ethiopia be a springboard or a stonewall for GM crops in Africa?

Tesfaye (Shiferaw) Sida
Correspondence 29 Jan 2021
Building a high-quality Human Cell Atlas

Orit Rozenblatt-Rosen
Jay W. Shin
Holger Heyn
Correspondence 26 Jan 2021

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Features

Patents
- Liquid biopsy
  
  Recent patents relating to devices, kits and detection methods for liquid biopsy.
  
  Patents 09 Feb 2021

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News & Views

Podcast
- First Rounders: Grace Colón
  
  Podcast 08 Jan 2021

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Research

Matters Arising
- Initialization is critical for preserving global data structure in both t-SNE and UMAP
  
  Dmitry Kobak
  George C. Linderman
  Matters Arising 01 Feb 2021
- UMI or not UMI, that is the question for scRNA-seq zero-inflation
  
  Yingying Cao
  Simo Kitanovski
  Daniel Hoffmann
  Matters Arising 01 Feb 2021
- Reply to: UMI or not UMI, that is the question for scRNA-seq zero-inflation
  
  Valentine Svensson
  Matters Arising 01 Feb 2021
Brief Communications
- Deep brain optogenetics without intracranial surgery
  
  Optogenetic control of neural activity in the deep brain is achieved without intracranial surgery using ChRmine.
  
  Ritchie Chen
  Felicity Gore
  Karl Deisseroth
  Brief Communication 05 Oct 2020
- Context-aware dimensionality reduction deconvolutes gut microbial community dynamics
  
  Gut microbiome composition is associated with phenotypes as revealed by a dimensionality reduction tool.
  
  Cameron Martino
  Liat Shenhav
  Rob Knight
  Brief Communication 31 Aug 2020
- Auto-deconvolution and molecular networking of gas chromatography–mass spectrometry data
  
  A machine learning workflow enables auto-deconvolution of gas chromatography–mass spectrometry data.
  
  Alexander A. Aksenov
  Ivan Laponogov
  Kirill Veselkov
  Brief Communication 09 Nov 2020
- Isolating live cell clones from barcoded populations using CRISPRa-inducible reporters
  
  Cell clones in lineage-tracing studies can be isolated for functional experiments.
  
  Christian Umkehrer
  Felix Holstein
  Anna C. Obenauf
  Brief Communication 27 Jul 2020
Letters
- Epineural optogenetic activation of nociceptors initiates and amplifies inflammation
  
  An optogenetic study shows that activation of pain-triggering sensory neurons induces an immune response.
  
  Frédéric Michoud
  Corey Seehus
  Stéphanie P. Lacour
  Letter 21 Sept 2020
Articles
- Single-cell metabolic profiling of human cytotoxic T cells
  
  An antibody-based method enables profiling of metabolic protein expression and regulation in single cells using mass spectrometry.
  
  Felix J. Hartmann
  Dunja Mrdjen
  Sean C. Bendall
  Article 31 Aug 2020
- Predicting the efficiency of prime editing guide RNAs in human cells
  
  Prime editing is optimized by a method to choose the most efficient guide RNA.
  
  Hui Kwon Kim
  Goosang Yu
  Hyongbum Henry Kim
  Article 21 Sept 2020
- Characterizing allele- and haplotype-specific copy numbers in single cells with CHISEL
  
  Genomic copy-number aberrations in single cells are identified with allele specificity.
  
  Simone Zaccaria
  Benjamin J. Raphael
  Article 02 Sept 2020
- Oncoprotein-specific molecular interaction maps (SigMaps) for cancer network analyses
  
  Interaction networks for any protein can be generated using a machine learning algorithm.
  
  Joshua Broyde
  David R. Simpson
  Andrea Califano
  Article 14 Sept 2020
- Direct DNA crosslinking with CAP-C uncovers transcription-dependent chromatin organization at high resolution
  
  CAP-C uses multifunctional DNA crosslinkers of defined sizes to increase resolution and signal-to-noise in chromosome conformation capture experiments.
  
  Qiancheng You
  Anthony Youzhi Cheng
  Chuan He
  Article 24 Aug 2020
Analysis
- Benchmarking of T cell receptor repertoire profiling methods reveals large systematic biases
  
  A comparison of T cell receptor repertoire profiling methods shows substantial differences in their outputs.
  
  Pierre Barennes
  Valentin Quiniou
  Encarnita Mariotti-Ferrandiz
  Analysis 07 Sept 2020

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Amendments & Corrections

Publisher Correction: COVID-19 antibodies on trial

Laura DeFrancesco
Publisher Correction 08 Jan 2021

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Careers & Recruitment

Career Feature
- Fourth-quarter biotech job picture
  
  A quarterly snapshot of job expansions, reductions and availability in the biotech and pharma sectors.
  
  Michael Francisco
  Career Feature 09 Feb 2021
People
- People
  
  Recent moves of note in and around the biotech and pharma industries.
  
  People 09 Feb 2021

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Volume 39 Issue 2, February 2021

How pain receptors drive inflammation

Editorial

News

Data Page

News Feature

Correspondence

Features

Patents

News & Views

Podcast

Research

Matters Arising

Brief Communications

Letters

Articles

Analysis

Amendments & Corrections

Careers & Recruitment

Career Feature

People

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