Volume 39 Issue 3, March 2021

For most of its history, biomedical research and clinical testing has neglected over half of the world’s population. Finally, researchers and funders are starting to recognize the importance of sex differences.

Implications for bioentrepreneurs.

The scope of patents covering SARS-CoV-2 and diagnostics, vaccines and treatments related to the virus remains unclear, but the pandemic may have created a permanent demand for SARS-CoV-2-related products and spark long-term interest in relevant intellectual property rights.

Recent patents relating to methods of preparing DNA sequencing libraries for metagenomic analysis and systems for processing metagenomic data.

An analysis of Massachusetts Institute of Technology intellectual property licenses in the life sciences not only provides a window on commercialization success but also a case study for transparency in understanding technology transfer performance.

Assembly of haplotype-resolved human genomes is achieved by combining short and long reads.

Assembly of phased human genomes is achieved by combining long reads and long-range conformational data.

An improved method for spatial transcriptomics with detection efficiency approaching that of droplet-based single-cell RNA-seq techniques.

The age of individual RNA molecules at 1-h resolution is inferred by measuring A-to-I editing.

A paralyzed individual controls a neuroprosthetic without daily recalibration.

Using long reads to probe RNA structure reveals differences between transcript isoforms.

Networks of proteins bound to single RNAs are identified by correlated chemical crosslinking.

Triple-negative breast cancer is inhibited by depleting mitochondrial copper in mice.

A near-infrared fluorescent calcium indicator can be combined with other optogenetic tools in vivo without spectral crosstalk.

DNA origami orients single proteins on a surface to aid structure determination by cryo-electron microscopy.

As the implementation of artificial intelligence and machine learning technologies progresses toward the clinic, the traditional roles of physicians will change.

Recent moves of note in and around the biotech and pharma industries.