Volume 41 Issue 10, October 2023

Editorial

The community of the DAO

Decentralized autonomous organizations are growing as alternative research funding models, but are also strong scientific communities. We should get on board.

Editorial 02 Oct 2023

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News

Scientists hone tools to measure aging and rejuvenation interventions

Aging is malleable, at least in animal models. But to prove the efficacy of interventions aimed at extending healthspan and to test life-extending approaches in humans, longevity researchers first need to agree on the best measuring tools. With the power of ’omics, AI and large biobanks, improved biomarkers may be forthcoming. Companies and academic researchers are rallying forces, but how far have they gotten?

Lisa Melton
News 22 Aug 2023
New guise ADCs couple antibodies to degraders

News in Brief 12 Oct 2023
Upswing in AI drug-discovery deals

News in Brief 12 Oct 2023
From air to your plate: tech startups making food from atmospheric CO₂

Food tech companies are taking bacteria that capture CO₂ from air to make edible and nutritious food and drink.

Claire Turrell
News 26 Sept 2023
Autoimmune neuroinflammation newco

News in Brief 12 Oct 2023
Biotech news from around the world

News in Brief 12 Oct 2023
News Feature
- Pharma deal making: a bright spot amid the gloom
  
  Biopharma M&A is back and IPOs are possible, but most biotechs aren’t out of the woods.
  
  Melanie Senior
  News Feature 15 Sept 2023

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Correspondence

The long game of tenure

Todd J. Treangen
Moshe Y. Vardi
Correspondence 25 Aug 2023
Tenure time loopers

Nozomu Yachie
Nika Shakiba
Correspondence 25 Aug 2023
A new chance for genome editing in Europe

Hervé Vanderschuren
Patience Chatukuta
Devang Mehta
Correspondence 14 Sept 2023

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Features

Patents
- Are ecological processes that select beneficial traits in agricultural microbes nature’s intellectual property rights?
  
  Novel beneficial traits in agricultural microbes represent inventive steps of nature, but the inability of patent laws to reward nonhuman inventors has led to conflicts over microbial ownership rights and presents barriers to the sharing of benefits.
  
  David Kothamasi
  Saskia Vermeylen
  Sharma Deepika
  Patents 12 Oct 2023
- Antimicrobials
  
  Recent patents relating to the production of antimicrobial agents and materials.
  
  Patents 12 Oct 2023

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Research Highlights

Implantable biosensor tracks temperature to detect early transplant rejection in rats

Anahita Bishop
Research Highlight 12 Oct 2023
Advancing missense variant pathogenicity prediction

Rong Li
Research Highlight 12 Oct 2023
Monitoring protein proximity with fluorogens

Alexandra Despang
Research Highlight 12 Oct 2023

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News & Views

CRISPR editing in the lung with novel lipids

CRISPR RNA is delivered to the mouse lung by inhalation using improved lipid nanoparticles.

Uri Elia
Edo Kon
Dan Peer
News & Views 30 Mar 2023
Human microbiome cultivation expands with AI

An automated system for picking bacterial colonies is used to create a biobank of personalized microbiomes.

Marta Selma-Royo
Nicola Segata
Liviana Ricci
News & Views 22 Jun 2023
Speed reading the epigenome and genome

Dual sequencing of the epigenome and genome could have broad implications in oncology.

James M. George
Arul M. Chinnaiyan
News & Views 21 Apr 2023

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Research Briefings

Lipid nanoparticle-enabled gene editing in the lung via inhalation

The ability to create in vivo genomic medicines for tissues other than the liver has been impeded by difficulties in delivery. Using a high-throughput platform, we developed lipid nanoparticles that can effectively deliver mRNA and CRISPR–Cas9 gene editing tools to the lungs through intratracheal administration, expanding the potential clinical uses of gene editing and mRNA-based technologies.

Research Briefing 30 Mar 2023
Computational framework decomposes and annotates single-cell and spatial omics

We developed TACCO, a versatile and efficient computational annotation framework, leveraging growing single-cell and spatial omics data to identify cell types and states, decipher molecular and cellular tissue structure, and resolve differentiation trajectories.

Research Briefing 16 Feb 2023

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Research

Brief Communications
- Interstrand crosslinking of homologous repair template DNA enhances gene editing in human cells
  
  The efficiency of homologous recombination is increased by crosslinking template DNA.
  
  Hannah I. Ghasemi
  Julien Bacal
  Chris D. Richardson
  Brief Communication Open Access 27 Feb 2023
- High-plex protein and whole transcriptome co-mapping at cellular resolution with spatial CITE-seq
  
  Co-indexing of transcriptomes and epitopes is extended to the spatial dimension with large protein panels.
  
  Yang Liu
  Marcello DiStasio
  Rong Fan
  Brief Communication Open Access 23 Feb 2023
- Combinatorial design of nanoparticles for pulmonary mRNA delivery and genome editing
  
  A high-throughput screen improves lipid nanoparticle delivery of gene editors in the lung.
  
  Bowen Li
  Rajith Singh Manan
  Daniel Anderson
  Brief Communication 30 Mar 2023
Articles
- gutSMASH predicts specialized primary metabolic pathways from the human gut microbiota
  
  Taxon-specific primary metabolic pathways are identified using profile hidden Markov models.
  
  Victòria Pascal Andreu
  Hannah E. Augustijn
  Marnix H. Medema
  Article 13 Feb 2023
- High-throughput microbial culturomics using automation and machine learning
  
  A machine learning isolation and genotyping platform enable high-throughput bacterial culture generation.
  
  Yiming Huang
  Ravi U. Sheth
  Harris H. Wang
  Article Open Access 20 Feb 2023
- Synapse-tuned CARs enhance immune cell anti-tumor activity
  
  Synapse-tuned CAR immune cells effectively kill solid tumor cells.
  
  Peter J. Chockley
  Jorge Ibanez-Vega
  Stephen Gottschalk
  Article 02 Feb 2023
- Prediction of prime editing insertion efficiencies using sequence features and DNA repair determinants
  
  Prime editing efficiency is affected by insertion sequence features, secondary structure and DNA repair context.
  
  Jonas Koeppel
  Juliane Weller
  Leopold Parts
  Article Open Access 16 Feb 2023
- Simultaneous sequencing of genetic and epigenetic bases in DNA
  
  A six-letter sequencing workflow can simultaneously detect genetic and epigenetic bases.
  
  Jens Füllgrabe
  Walraj S. Gosal
  Shankar Balasubramanian
  Article Open Access 06 Feb 2023
- TACCO unifies annotation transfer and decomposition of cell identities for single-cell and spatial omics
  
  Annotation transfer from reference to new datasets is improved with a probabilistic approach.
  
  Simon Mages
  Noa Moriel
  Mor Nitzan
  Article Open Access 16 Feb 2023
- Telomere-to-telomere assembly of diploid chromosomes with Verkko
  
  Integration of long and ultra-long reads results in improved phased, diploid assemblies.
  
  Mikko Rautiainen
  Sergey Nurk
  Sergey Koren
  Article 16 Feb 2023

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Amendments & Corrections

Author Correction: Unidirectional single-file transport of full-length proteins through a nanopore

Luning Yu
Xinqi Kang
Meni Wanunu
Author Correction 21 Sept 2023

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Careers & Recruitment

Career Feature
- A strategy to incentivize innovation in the health care system: the innovation RVU
  
  Encouraging innovation will allow physicians and their academic medical centers to pursue the development of technologies and healthcare practices that will improve patient care.
  
  Nathan V. Mallipeddi
  Jay Chandra
  Marc D. Succi
  Career Feature 12 Oct 2023
People
- People
  
  Recent moves of note in and around the biotech and pharma industries.
  
  People 12 Oct 2023

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Volume 41 Issue 10, October 2023

Inhalable delivery vehicles

Editorial

News

News Feature

Correspondence

Features

Patents

Research Highlights

News & Views

Research Briefings

Research

Brief Communications

Articles

Amendments & Corrections

Careers & Recruitment

Career Feature

People

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