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Volume 41 Issue 12, December 2023

Genetically encoded EM labels

Artistic impression of genetically encoded reporters for electron microscopy. Sigmund et al. combine heavy metal binders with proteins self-assembling into spherical shapes to generate six different concentric barcodes.

See Sigmund et al.

Image: Barth van Rossum. Cover Design: Erin Dewalt.

Volume 41 Issue 12

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Editorial

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News

  • Our ranking is out, and it has a few surprises. In pole position — predictably — is Wegovy, the weight-slashing GLP-1 agonist, with AI-hallucinated proteins a close second. These are followed by drugging options for RNA. The dark horses are virus-free gene therapies and a sweet protein.

    • Lisa Melton
    News

  • New tools are enabling companies to develop genetically engineered spider silk fibers that are as tough as steel, and as elastic as rubber.

    • Kenna Hughes-Castleberry
    News

  • News Feature

    • Nature Biotechnology’s annual survey highlights academic start ups that are, among other things, correcting misfolded or disordered proteins, creating second-generation GPCR agonists, building a new gene delivery platform and mining cancer genomes for novel targets.

      • Michael Eisenstein
      • Charles Schmidt
      • Laura DeFrancesco
      News Feature
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  • Genetically encoded concentric barcodes function as multiplexed electron microscopy (EM) gene reporters (EMcapsulins) for cell culture and in vivo models. These barcodes can be used to visualize gene expression information as automatically labeled overlays on volume EM data.

    Research Briefing

  • Fine-tuning gene expression is crucial for generating quantitative phenotypic changes and crop improvement. Using CRISPR–Cas base editing and prime editing, we engineered upstream open reading frames — eukaryotic translational control elements — in rice to incrementally downregulate translation to predictable and desired levels.

    Research Briefing

  • We have designed a method, binding affinities to native chromatin by sequencing (BANC-seq), to determine the transcription factor concentrations required for binding to regulatory elements across the genome. Our study shows that chromatin context and DNA accessibility are key regulators of transcription factor binding.

    Research Briefing
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