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Volume 42 Issue 1, January 2024

Multi-immersion mirror objectives

Neurons in the mouse hippocampus imaged with the Schmidt objective. Voigt et al. develop a multi-immersion objective based on a mirror instead of a lens.

See Voigt et al.

Image: Anna Maria Reuss and Fabian Voigt. Cover design: Erin Dewalt.

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  • Biotechnology (biotech) clusters have evolved over time. Being a top biotech region in the early years 1978–1990 still positively correlates with the cluster’s biotech strength decades later. An entrepreneurial orientation of scientific actors as well as a variety of networks with partners outside the cluster both contribute to sustained biotech activity.

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    • Grabowska Marcelina
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  • Transcription factors containing disordered regions can now be mapped across the genome, aiding functional studies.

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  • We present the Schmidt objective, a novel astronomy-inspired concept for designing multi-immersion microscope objectives with high numerical aperture, long working distance and large field of view. The Schmidt objective uses a spherical mirror and a correction plate to focus light. It is well suited for high-resolution imaging deep inside cleared biological samples.

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  • Nano-tRNAseq is a nanopore-based, cost-effective and high-throughput approach to quantify transfer RNA (tRNA) abundances and modifications simultaneously, providing a framework to study the ‘tRNAome’ at single-molecule resolution. We envision that Nano-tRNAseq will enable us to study the role of tRNA molecules and their modifications in a wide variety of contexts.

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    • Recent moves of note in and around the biotech and pharma industries.

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