Volume 41 Issue 6, June 2023

Editorial

Can microbes save the planet?

Genetic engineering and accelerated evolution of microbes aim to help climate change.

Editorial 01 Jun 2023

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News

Why gene therapies must go virus-free

Gene therapies have made spectacular progress in delivering new cures for previously intractable disease, but they remain the world’s most expensive treatments. Now companies are replacing the virus in gene therapies with new delivery technologies that promise not only to overcome the limitations of viral vectors but to slash production costs too.

Cormac Sheridan
News 14 Jun 2023
First herpesvirus gene therapy

News in Brief 14 Jun 2023
ADCs’ revival

News in Brief 14 Jun 2023
After GLP-1, what’s next for weight loss?

The GLP-1 agonist Wegovy has re-energized the hunt for obesity treatments. Alternatives — ranging from bitter taste compounds to lean muscle boosters and bacteria — are already in the clinic.

Melanie Senior
News 06 Jun 2023
Novo and Moderna seal base-editing pacts with Life Edit

News in Brief 14 Jun 2023
The instant spray-on dress

Lisa Melton
News 14 Jun 2023
Biotech news from around the world

News in Brief 14 Jun 2023
News Feature
- Drugging RNA
  
  Small molecules that target messenger RNA have therapeutic potential, but the field still lacks an unqualified success. Companies differ on how to move the resurgent field forward.
  
  Ken Garber
  News Feature 17 May 2023

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Correspondence

How will generative AI disrupt data science in drug discovery?

Jean-Philippe Vert
Correspondence 08 May 2023
New precision-breeding law unlocks gene editing in England

Mario Caccamo
Correspondence 09 May 2023
How the Monty Hall problem is similar to the false discovery rate in high-throughput data analysis

Jingyi Jessica Li
Correspondence 17 May 2023

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Features

Patents
- The global patent landscape of HER2-targeted biologics
  
  Global patents on HER2-targeted biologics show rapid growth and a diversified technology pattern.
  
  Qingjian Li
  Jiaqi Xu
  Herui Yao
  Patents 14 Jun 2023
- Drug delivery
  
  Recent patents relating to compositions, methods and devices for drug delivery.
  
  Patents 14 Jun 2023

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Research Highlights

Human gastrointestinal-tract variation catalogued

Jared B. Fudge
Research Highlight 14 Jun 2023
Combining 47 human genomes into a single pangenome

Jared B. Fudge
Research Highlight 14 Jun 2023
Electronic skin with onboard sensory feedback system

Jared B. Fudge
Research Highlight 14 Jun 2023

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Research Briefings

Single-cell nanobody-based profiles of multiple epigenetic modalities and chromatin velocity

Nanobody–Tn5 transposase fusion proteins enable detection of two histone marks and open chromatin regions at the same time, with single-cell resolution.

Research Briefing 19 Dec 2022
Multiplexed mapping of chromatin features at single-cell resolution

Single-cell nanobody-tethered transposition followed by sequencing (scNTT-seq) is a new assay that measures the genome-wide presence of multiple histone modifications and protein–DNA binding sites at single-cell resolution. scNTT-seq generates high-resolution multimodal maps of chromatin states with high accuracy and sensitivity.

Research Briefing 19 Dec 2022
Single-cell multi-omics allows functional characterization of structural variants

We developed a computational method based on Strand-seq that combines nucleosome occupancy and structural variation analysis in single cells to identify the functional effects of somatic structural variants in leukemia. The method revealed the molecular consequences of somatic driver mutations and informed specific therapeutic targeting of a chromothriptic leukemic subclone.

Research Briefing 24 Nov 2022

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Research

Review Articles
- The expanding vistas of spatial transcriptomics
  
  Spatial transcriptomics workflows, metrics and limitations are reviewed and discussed.
  
  Luyi Tian
  Fei Chen
  Evan Z. Macosko
  Review Article 03 Oct 2022
Brief Communications
- Identification of patient-specific CD4⁺ and CD8⁺ T cell neoantigens through HLA-unbiased genetic screens
  
  Patient-specific tumor neoantigens are recognized by T cells.
  
  Chiara M. Cattaneo
  Thomas Battaglia
  Wouter Scheper
  Brief Communication Open Access 02 Jan 2023
- Integration of whole transcriptome spatial profiling with protein markers
  
  Visium spatial transcriptomics is combined with markers for more than 30 proteins.
  
  Nir Ben-Chetrit
  Xiang Niu
  Dan A. Landau
  Brief Communication 02 Jan 2023
Articles
- Multimodal chromatin profiling using nanobody-based single-cell CUT&Tag
  
  Three epigenetic features are mapped at single-cell resolution using Tn5-nanobody fusion proteins
  
  Marek Bartosovic
  Gonçalo Castelo-Branco
  Article Open Access 19 Dec 2022
- Nanobody-tethered transposition enables multifactorial chromatin profiling at single-cell resolution
  
  Cell surface protein expression and multiple epigenetic features are mapped simultaneously in single cells.
  
  Tim Stuart
  Stephanie Hao
  Ivan Raimondi
  Article 19 Dec 2022
- scChIX-seq infers dynamic relationships between histone modifications in single cells
  
  Analysis of two histone marks in single cells reveals interplay between modifications.
  
  Jake Yeung
  Maria Florescu
  Alexander van Oudenaarden
  Article Open Access 02 Jan 2023
- In vivo development of immune tissue in human intestinal organoids transplanted into humanized mice
  
  Human intestinal organoids are endowed with immune cells by transplantation into humanized mice.
  
  Carine Bouffi
  Kathryn A. Wikenheiser-Brokamp
  Michael A. Helmrath
  Article Open Access 26 Jan 2023
- Functional analysis of structural variants in single cells using Strand-seq
  
  Linking structural variants to gene expression information identifies aberrant signaling pathways.
  
  Hyobin Jeong
  Karen Grimes
  Jan O. Korbel
  Article Open Access 24 Nov 2022
- A proteome-wide atlas of drug mechanism of action
  
  A proteome-wide atlas of the effect of 875 compounds reveals mechanisms of action and off-target effects.
  
  Dylan C. Mitchell
  Miljan Kuljanin
  Steven P. Gygi
  Article 02 Jan 2023
- Magnify is a universal molecular anchoring strategy for expansion microscopy
  
  Expansion microscopy with gel-anchored molecules enables simultaneous retention of nucleic acids, proteins and lipids in diverse tissue types.
  
  Aleksandra Klimas
  Brendan R. Gallagher
  Yongxin Zhao
  Article Open Access 02 Jan 2023
- Control-independent mosaic single nucleotide variant detection with DeepMosaic
  
  A deep learning model detects low frequency mosaic variants with improved accuracy.
  
  Xiaoxu Yang
  Xin Xu
  Joseph G. Gleeson
  Article 02 Jan 2023

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Careers & Recruitment

Career Feature
- What is hindering the drug development industry from achieving diversity, equity and inclusion in its workforce?
  
  Establishing accountability by implementing measurable metrics to track and monitor DEI dynamics can ensure that it becomes central to an organization’s strategy.
  
  Jennifer Y. Kim
  Emily Botto
  Career Feature 14 Jun 2023
People
- People
  
  Recent moves of note in and around the biotech and pharma industries.
  
  People 14 Jun 2023

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Volume 41 Issue 6, June 2023

Expansion microscopy

Editorial

News

News Feature

Correspondence

Features

Patents

Research Highlights

Research Briefings

Research

Review Articles

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Articles

Careers & Recruitment

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