Volume 41 Issue 7, July 2023

Editorial

Prize-winning spinoffs

Early-stage researchers win Spinoff Prize with a clinical bioadhesive.

Editorial 05 Jul 2023

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News

‘Clicked’ drugs: researchers prove the remarkable chemistry in humans

Bioorthogonal click chemistry is being used in patients to help target cancer medicines and diagnostic imaging agents

Mark Peplow
News 05 Jul 2023
Targeted glioma therapy makes strides

News in Brief 14 Jul 2023
Verve to edit gene for coronary risk lipid Lp(a)

News in Brief 14 Jul 2023
Unprecedented blood biomarker enables ALS drug approval

Biogen’s drug Qalsody is the first drug to gain approval for a genetically defined form of ALS, but there is more to come as developers zoom in on a wide range of disease targets.

Cormac Sheridan
News 29 Jun 2023
Eight diseases for gene therapy accelerator

News in Brief 14 Jul 2023
So sweet, no spike

Lisa Melton
News 14 Jul 2023
Biotech news from around the world

News in Brief 14 Jul 2023
Data Page
- Biotech patenting — 2022
  
  Kathryn Paisner
  Laura DeFrancesco
  Data Page 14 Jul 2023

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Correspondence

Plant molecular farming in the wake of the closure of Medicago Inc

Eugenio Benvenuto
Inge Broer
Julian Ma
Correspondence 22 May 2023
A call for an ‘Asilomar’ for cultivated meat and seafood

Sveva Bottini
Claudia Fuoco
Cesare Gargioli
Correspondence 15 Jun 2023
Guidelines for public database submission of uncultivated virus genome sequences for taxonomic classification

Evelien M. Adriaenssens
Simon Roux
Bas E. Dutilh
Correspondence 10 Jul 2023

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Features

Patents
- The prevalence of drug patent term extensions in the United States, 2000–2018
  
  Drug patents that are given patent term extension are important bellwether indicators for generic drug market entry.
  
  Victor L. Van de Wiele
  Aaron S. Kesselheim
  S. Sean Tu
  Patents 14 Jul 2023
- Machine learning in drug discovery
  
  Recent patents relating to machine learning in drug discovery and screening.
  
  Patents 14 Jul 2023

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Research Highlights

Transplanting soil microbial communities improves climate tolerance in trees

Julie N. Chuong
Research Highlight 14 Jul 2023
Fluorescence microscopy resolution increases to near-atomic level

Julie N. Chuong
Research Highlight 14 Jul 2023
Multiplex-GAM detects complex chromatin interactions

Julie N. Chuong
Research Highlight 14 Jul 2023

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News & Views

CRISPR-edited plants by grafting

Edited, transgene-free plants are produced without tissue culture by RNA migration from rootstocks to grafts.

Jiacheng Hu
Caixia Gao
News & Views 02 Jan 2023
Staple crops equipped for alkaline soils

Gene editing boosts the yields of sorghum, rice and millet grown in alkaline soils.

Caitlin S. Byrt
A. Harvey Millar
Rana Munns
News & Views 12 Jun 2023

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Research Briefings

Real-time monitoring of tumor-homing bacteria and tumor cells in vivo using ultrasound

By screening natural prokaryotic gas vesicle gene clusters, we found and engineered new acoustic reporter genes (ARGs) that give bacteria and mammalian cells brighter ultrasound contrast for real-time noninvasive imaging. Expressing these ARGs in engineered cells enabled us to image tumor-homing bacteria and perform genetically guided tumor biopsies in vivo.

Research Briefing 02 Jan 2023

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Research

Brief Communications
- Accurate isoform discovery with IsoQuant using long reads
  
  IsoQuant predicts novel isoforms from long-read RNA sequencing.
  
  Andrey D. Prjibelski
  Alla Mikheenko
  Hagen U. Tilgner
  Brief Communication Open Access 02 Jan 2023
Articles
- Genomically mined acoustic reporter genes for real-time in vivo monitoring of tumors and tumor-homing bacteria
  
  Gene expression is imaged in deep tissues in mice using ultrasound.
  
  Robert C. Hurt
  Marjorie T. Buss
  Mikhail G. Shapiro
  Article Open Access 02 Jan 2023
- Facile repurposing of peptide–MHC-restricted antibodies for cancer immunotherapy
  
  A method to identify antibodies against peptide–MHC complexes could enable patient-specific cancer immunotherapeutics.
  
  Xinbo Yang
  Daisuke Nishimiya
  K. Christopher Garcia
  Article Open Access 02 Jan 2023
- A genetically encoded sensor measures temporal oxytocin release from different neuronal compartments
  
  A sensor for oxytocin reveals mechanisms of oxytocin action with high spatiotemporal precision.
  
  Tongrui Qian
  Huan Wang
  Yulong Li
  Article 02 Jan 2023
- Heritable transgene-free genome editing in plants by grafting of wild-type shoots to transgenic donor rootstocks
  
  Gene-edited plants free of CRISPR-associated sequences are generated by grafting.
  
  Lei Yang
  Frank Machin
  Friedrich Kragler
  Article Open Access 02 Jan 2023
- Precise cut-and-paste DNA insertion using engineered type V-K CRISPR-associated transposases
  
  Engineered CRISPR-associated transposases improve the purity and specificity of DNA insertions.
  
  Connor J. Tou
  Benno Orr
  Benjamin P. Kleinstiver
  Article 02 Jan 2023
- High-throughput, targeted MHC class I immunopeptidomics using a functional genetics screening platform
  
  Peptides that bind MHC class I are readily identified with a programmable, high-throughput method.
  
  Peter M. Bruno
  Richard T. Timms
  Stephen J. Elledge
  Article 02 Jan 2023
- Transcriptome-wide profiling and quantification of N⁶-methyladenosine by enzyme-assisted adenosine deamination
  
  N⁶-methyladenosine is mapped at single-base resolution in as few as ten cells.
  
  Yu-Lan Xiao
  Shun Liu
  Weixin Tang
  Article 02 Jan 2023
- A spatial genome aligner for resolving chromatin architectures from multiplexed DNA FISH
  
  The architectures of chromatin fibers are resolved using a spatial genome aligner.
  
  Bojing Blair Jia
  Adam Jussila
  Bing Ren
  Article Open Access 02 Jan 2023
- Dynamic, adaptive sampling during nanopore sequencing using Bayesian experimental design
  
  Nanopore selective sequencing with real-time decision updates mitigates coverage bias.
  
  Lukas Weilguny
  Nicola De Maio
  Nick Goldman
  Article Open Access 02 Jan 2023

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Amendments & Corrections

Author Correction: Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models

Rosa Lundbye Allesøe
Agnete Troen Lundgaard
Moustafa Abdalla
Author Correction Open Access 02 May 2023
Author Correction: A spatial genome aligner for resolving chromatin architectures from multiplexed DNA FISH

Bojing Blair Jia
Adam Jussila
Bing Ren
Author Correction Open Access 16 Jan 2023

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Careers & Recruitment

Career Feature
- The need for need-finding in medical education
  
  The paradigm of developing a novel technology and applying it to a clinically relevant problem may be dominant in academic medicine, but more emphasis is needed in identifying important clinical problems before looking for solutions.
  
  Sainiteesh Maddineni
  Wasan Kumar
  Career Feature 14 Jul 2023
- Five questions with Sanja Vicković
  
  A pioneer in spatially resolved transcriptomics and genomics methods recounts her journey from professional ice hockey player to running her own lab.
  
  Michael Francisco
  Career Feature 14 Jul 2023
People
- People
  
  Recent moves of note in and around the biotech and pharma industries.
  
  People 14 Jul 2023

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Volume 41 Issue 7, July 2023

Seeing cells with sound

Editorial

News

Data Page

Correspondence

Features

Patents

Research Highlights

News & Views

Research Briefings

Research

Brief Communications

Articles

Amendments & Corrections

Careers & Recruitment

Career Feature

People

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