Volume 41 Issue 8, August 2023

Editorial

Not-so-creepy crawlies

Biotech is embracing insect protein as a meat alternative. Will the rest of the population follow?

Editorial 03 Aug 2023

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News

Innovators hit by ruling in dispute over cholesterol antibody patent

The US Supreme Court decision in the Amgen vs. Sanofi patent dispute over PCSK9 inhibitors puts a decisive end to broad patents claiming rights over all molecules directed at a given target.

Charlotte Harrison
News 11 Aug 2023
First cell therapy for diabetes approved

News in Brief 11 Aug 2023
Fungal architecture is a thing, and it’s eye-catching

Lisa Melton
News 11 Aug 2023
US approves ‘no kill’ meat for sale

News in Brief 11 Aug 2023
CRISPR upgrades insect proteins for feed

A new generation of companies is pursuing insect larvae as a protein source for animal feed, fertilizer, biofuels and even as ingredients for burgers and shakes. The insects promise to deliver cheaper and more sustainable alternatives to soy and fishmeal, with the added benefit that larvae can be raised on organic waste.

Karl Gruber
Lisa Melton
News 11 Aug 2023
Gates, Wellcome rekindle TB vaccine

Collection:

Tuberculosis
News in Brief 11 Aug 2023
Biotech news from around the world

News in Brief 11 Aug 2023
Data Page
- Drug pipeline 2Q23 — controversy and complexity
  
  John Hodgson
  Data Page 27 Jul 2023
- 2Q23 — merger premiums reveal valuation gulf
  
  John Hodgson
  Data Page 27 Jul 2023
News Feature
- Bat biotech takes flight
  
  Harnessing the unusual biology of bats, researchers aim to turn drug discovery upside-down.
  
  Elie Dolgin
  News Feature 17 Jul 2023

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Correspondence

Defining a longevity biotechnology company

Nicola Boekstein
Nir Barzilai
James Peyer
Correspondence 26 Jun 2023
Democratizing knowledge representation with BioCypher

Sebastian Lobentanzer
Patrick Aloy
Julio Saez-Rodriguez
Correspondence 19 Jun 2023
FAIR data policies can benefit biotech startups

Kate Hardy
Stephan Heyse
Correspondence 11 Aug 2023

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Features

Patents
- Comparing efficiency of patent production between US institutions using a hybrid NIH–USPTO dataset
  
  A database that links patents to NIH awards enables evaluation of key milestones along the research translation pathway.
  
  Rocco M. DiSanto
  Mark Van Dyke
  Robert G. Gourdie
  Patents 11 Aug 2023
- RNA-based therapies
  
  Recent patents relating to the composition, preparation and optimization of RNA-based therapies.
  
  Patents 11 Aug 2023

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Research Highlights

Spatial transcriptomics of the human heart

Jared B. Fudge
Research Highlight 11 Aug 2023
Diffusion model expands RoseTTAFold’s power

Jared B. Fudge
Research Highlight 11 Aug 2023
Models of the early human embryo

Jared B. Fudge
Research Highlight 11 Aug 2023

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News & Views

Hallucinating functional protein sequences

Functional proteins with limited homology to natural proteins are designed using a large language model.

David Belanger
Lucy J. Colwell
News & Views 26 Jan 2023
Podcast
- Forum: Boyden and Danzl
  
  Podcast 11 Aug 2023

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Research Briefings

Single-cell recording of cellular RNAs in bacteria

The collection of RNAs in a cell reflects its identity and behavior. Although probing these RNAs in the present is commonplace, peering into the past remains challenging. We developed TIGER (transcribed RNAs inferred by genetically encoded records) to record selected RNAs at the single-cell level, enabling us to connect the past with the present.

Research Briefing 05 Jan 2023
Protein identification using a digestion-free nanopore approach

Sequencing of proteins is a technically difficult task that typically requires digestion into short peptides before detection and identification. We developed a digestion-free method to chemically unfold and ‘scan’ full-length proteins through a nanopore, producing electrical fingerprints unique to individual protein molecules that are useful in their identification.

Research Briefing 09 Jan 2023

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Research

Brief Communications
- Programmable A-to-Y base editing by fusing an adenine base editor with an N-methylpurine DNA glycosylase
  
  A base editor is engineered for A-to-T and A-to-C transversion editing.
  
  Huawei Tong
  Xuchen Wang
  Hui Yang
  Brief Communication 09 Jan 2023
- Solid-phase capture and profiling of open chromatin by spatial ATAC
  
  Chromatin accessibility profiles are spatially resolved in tissue sections.
  
  Enric Llorens-Bobadilla
  Margherita Zamboni
  Patrik L. Ståhl
  Brief Communication Open Access 05 Jan 2023
Articles
- Engineered live bacteria suppress Pseudomonas aeruginosa infection in mouse lung and dissolve endotracheal-tube biofilms
  
  A bacterium expressing antibacterial genes treats a lung infection associated with mechanical ventilators.
  
  Rocco Mazzolini
  Irene Rodríguez-Arce
  Maria Lluch-Senar
  Article Open Access 19 Jan 2023
- Large language models generate functional protein sequences across diverse families
  
  A generative deep-learning model designs artificial proteins with desired enzymatic activities.
  
  Ali Madani
  Ben Krause
  Nikhil Naik
  Article 26 Jan 2023
- RNA recording in single bacterial cells using reprogrammed tracrRNAs
  
  RNA transcripts in bacteria are recorded as DNA modifications using a base editor.
  
  Chunlei Jiao
  Claas Reckstadt
  Chase L. Beisel
  Article Open Access 05 Jan 2023
- A universal deep-learning model for zinc finger design enables transcription factor reprogramming
  
  Zinc finger design is facilitated with a deep-learning model.
  
  David M. Ichikawa
  Osama Abdin
  Marcus B. Noyes
  Article Open Access 26 Jan 2023
- Unidirectional single-file transport of full-length proteins through a nanopore
  
  Full-length, unfolded proteins are slowly translocated through nanopores without enzymes and fingerprinted.
  
  Luning Yu
  Xinqi Kang
  Meni Wanunu
  Article 09 Jan 2023
- Cell-type-specific prediction of 3D chromatin organization enables high-throughput in silico genetic screening
  
  Deep learning predicts cell-type-specific 3D chromatin contacts from DNA sequence, chromatin accessibility and CTCF binding.
  
  Jimin Tan
  Nina Shenker-Tauris
  Aristotelis Tsirigos
  Article Open Access 09 Jan 2023
- Predicting prime editing efficiency and product purity by deep learning
  
  The design of prime editing guide RNAs is optimized by deep learning.
  
  Nicolas Mathis
  Ahmed Allam
  Gerald Schwank
  Article 16 Jan 2023
- Real-time, volumetric imaging of radiation dose delivery deep into the liver during cancer treatment
  
  Radiation dose delivery is measured in real time for a patient with cancer.
  
  Wei Zhang
  Ibrahim Oraiqat
  Issam El Naqa
  Article Open Access 02 Jan 2023

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Careers & Recruitment

Career Feature
- Grand challenges in bioinformatics education and training
  
  With the increasing need for bioinformatics expertise in the life sciences, a coordinated effort is needed to proactively and critically reflect on the challenges of educating and training life scientists with the necessary skills and competencies.
  
  Esra Büşra Işık
  Michelle D. Brazas
  Asif M. Khan
  Career Feature 11 Aug 2023
- 1H23 biotech job picture
  
  A semiannual snapshot of job expansions, reductions and availability in the biotech and pharma sectors.
  
  Michael Francisco
  Career Feature 11 Aug 2023
People
- People
  
  Recent moves of note in and around the biotech and pharma industries.
  
  People 11 Aug 2023

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Volume 41 Issue 8, August 2023

Nanopores

Editorial

News

Data Page

News Feature

Correspondence

Features

Patents

Research Highlights

News & Views

Podcast

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Research

Brief Communications

Articles

Careers & Recruitment

Career Feature

People

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