Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
The authors report a molecular ferroelectric (TMCM)[FeCl4], which shows strong magnetostrictive and magnetoelectric effects at room temperature. The spin-lattice coupling of FeCl4 and flexible structure of organic cations are responsible for these effects.
The study links heavy past rainfall events in Svalbard to Scandinavian blocking. Lake sediment data spanning the last 2 millennia warns of worse floods with continued warming, especially intense during atmospheric blocking conditions.
Rare-earth elements (REEs) are vital to the modern economy, yet their mining poses both geopolitical and environmental challenges. Here, authors present a highly selective method for the recovery of europium from spent fluorescent lamps using redox active tetrathiotungstate ligands.
IL-12 has been shown to enhance the efficacy of anti-PD-1 therapy, but this has been hampered by issues with toxicity and poor delivery to the tumour site. In this study, the authors generate an anti-PD-1 antibody/IL-12 fusion protein for specific targeting of IL-12 to tumour sites, resulting in potent anti-tumour immunity with limited toxicity.
BAX and BAK are proapoptotic proteins that directly mediate mitochondrial outer membrane permeabilization (MOMP). Here, lipidomics and other data provide insight on how local lipid environment affects BAX and BAK function during apoptosis, suggesting that unsaturated lipids promote BAX pore activity.
The use of CTLA4-Ig fusion proteins in transplantation remains limited due to co-stimulation blockade-resistant rejection (CBRR). In this study, the authors demonstrate that IL-6 blockade reduces CBRR in murine cardiac transplants in the context of T cell-depleting induction regimens and CTLA4-Ig treatment.
Diagnostic blood-based biomarkers of pediatric IBD are limited. Here, the authors demonstrate a diagnostic lipidomic signature, comprising only of two molecular lipids. Translation of this signature into a scalable test has the potential to support clinical decision making.
Vaccines and clean water shortages continue to give rise to cholera outbreaks in Africa. Coordinated efforts to increase vaccine distribution and improve physical infrastructure are needed while considering future outbreaks and water demands due to conflicts and climate events.
Activated GPCRs signal through multiple pathways. Ligands that signal through a single pathway are highly valued. The authors demonstrate that tethering ligands to receptors via conjugation with binding nanobodies enables pathway-specific signaling.
Here the authors connect inherited Apolipoprotein E genotype with the risk of developing Alzheimer’s disease by demonstrating how, in an isoform- and lipidation-specific way, apoE modulates the aggregation, clearance and toxicity of Amyloid-beta.
Transfer learning has shown an advantageous performance in various tasks, however pretraining of the model with new dataset remains computationally expensive. The authors propose a biologically inspired three-dimensional neural network model for transfer learning, with improved training speed and accuracy.
Palladium-based catalysts are highly effective for the complete oxidation of methane. Here, the authors employ operando transmission electron microscopy, near-ambient pressure X-ray photoelectron spectroscopy, and density functional theory calculations to investigate the active state and catalytic function of Pd nanoparticles in methane oxidation.
Revealing catalyst structural evolution during catalysis is critical. Here, authors reveal that a Cu-Ag oxide precursor undergoes a transformation during CO electroreduction to a composite consisting of Ag nanoparticles enveloped by thin layers of amorphous Cu, which is likely the real active phase.
Elevation of IL-6 during cancer progression has been shown to drive cancer cachexia, however, while brain dysfunction has been reported, the underlying mechanism is unclear. Here, the authors identify neurons in the area postrema as a mediator of peripheral IL-6 in preclinical models of cancer cachexia.
Mitochondrial tRNAs are less structurally stable than nuclear tRNAs, and their maturation pathway is unique. Here, the authors reveal how human mitochondrial precursor tRNAs are recognised, processed, methylated and prepared for full functionality in mitochondrial translation.
Variants of the 3′−5′ exonuclease TREX1 can cause retinal vasculopathy with cerebral leukoencephalopathy (RVCL). Here, the authors show that RVCL-associated TREX1 variants trigger DNA damage in humans, mice, and Drosophila, and render cells more vulnerable to DNA damage inducing agents.
Guan et al. identify a male gametocyte-specific RNA-binding protein RBPm1 in the malaria parasite. RBPm1 controls the intron splicing of axonemal genes. RBPm1- deficient parasites fail to assemble the axoneme for male gametogenesis and thus mosquito transmission of Plasmodium.
Here, the authors develop a deep-learning algorithm to predict biomarkers from histopathological imaging in advanced urothelial cancer patients. This method detects suitable patients for targeted therapy clinical trials with a significant reduction in molecular testing, providing cost and time savings in real-world clinical settings.
This study presents EMDiffuse, a software suite based on diffusion models which augments electron microscopy imaging. EMDiffuse enhances electron microscopy images and enables isotropic reconstruction of volume electron microscopy data, suitable for investigating biological nanostructures.