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Room-temperature phosphorescence is usually inefficient in purely organic material. Here, the authors achieve near-unity phosphorescence efficiency with color tunability in adaptive host-guest materials through use of hyperconjugation.
The nucleus accumbens integrates sleep and motivation in mice. Here, the authors show sleep induction by increasing the activity of extracellular adenosine from astrocytes and neurons at A2A receptors with a photoactivatable allosteric modulator.
Plastic pollution severely threatens the resilience of nature. Here, the authors utilize the spore-forming, polymer-degrading bacteria, Bacillus subtilis, as a living filler to develop biocomposite thermoplastic polyurethane with improved mechanical properties and biodegradation.
The molecular features of paediatric central nervous system (CNS) tumours are not fully understood, posing a challenge for targeted therapies. Here, the authors characterise paediatric CNS tumours using single-nucleus RNA-seq; they identify cell type populations associated with specific tumour types and with response to therapy.
CRISPR-Cas9 is a powerful tool, but the strict requirement for an “NGG” protospacer-adjacent motif (PAM) sequence limits the number of editable genes. Here the authors combine enzyme kinetics, cryo-EM, and single-molecule imaging to determine how SpRY interrogates DNA and recognises target sites for cleavage.
Cell type-specific epigenomic alterations and heterogeneity in paediatric central nervous system (CNS) tumours remain underexplored. Here, the authors integrate bulk DNA cytosine modification data with bulk and single-nucleus RNA-sequencing to explore cell type-specific epigenomic alterations and gene regulation in paediatric CNS tumours.
Evidence suggests that stress during development might lead to sexual dysfunction. Here, authors show that pubertal stress disrupted female sexual behavior by reducing activation of nitric oxide synthase-expressing neurons in response to male cues.
Leukaemia development has been reported as an associated risk of haematopoietic stem cell gene therapy (HSPC-GT) using retroviral vectors in different diseases. Here, the authors show a case of T-cell acute lymphoid leukaemia in a patient with Adenosine Deaminase-deficient Severe Combined Immunodeficiency (ADA-SCID) treated with retroviral gene therapy.
Here, the authors report that schizophrenia risk variants mapping to a striatal dopamine-related gene set are associated with increased striatal dopamine synthesis capacity and increased striatal activity during reward anticipation in humans.
Economic evaluation of utilization of digital technologies for cataract screening remains unknown. Here the authors show that digital hierarchical screening is cost-effective in China and annual screening proved to be the most cost-effective option.
The structure of a social network is thought to be heritable in many animals, including humans. Here, Rooke and colleagues identify a gene, which they name “degrees of kevin bacon (dokb)”, that is expressed in the central nervous system of Drosophila melanogaster and regulates the structure of social networks.
Two new gridded, model-ready historical biomass burning emission datasets (BB4CMIPpost and LPJ-LMfirepost) are developed by inverse modeling that leveraged 31 ice core records, existing emissions as a priori, and chemical transport model simulations.
The interaction between colon cancer cells and colonic epithelial cells (CECs) is critical yet not well-known. Here, the authors show that tumor extracellular vesicles mediate mitochondrial DNA transfer to CECs, initiating mitochondrial activation and RelA-induced TGFβ1 expression, leading to tumor progression.
In this work, Yang et al. provide evidence of triclosan exposure resulting in increased evolvability of K. pneumoniae in experimental evolution studies. They utilize sequencing and transcriptomics to explore the chromosomally and horizontally acquired antimicrobial resistance mechanisms.
Conventional dendritic cells are playing a pivotal role at the interface of innate and adaptive immunity, but they are a heterogenous group regarding function and regulation. Here, the authors show that although Bcl6-deficiency does not regulate general DC subset identity, Bcl6 expression is required for a specific subset of type 2 DCs in mice, resulting in impaired T helper cell responses and further clarifying molecular players driving DC subset heterogeneity.
This study explores selection signals of Papua New Guinean highlanders and lowlanders using 128 new whole genome sequences. It highlights two genetic variants associated with blood traits that also influence the heart rate of these populations.
The study of defects and boundaries in the context of conformal field theory is important but challenging in dimensions higher than two. Here the authors use the recently developed fuzzy sphere regularization approach to perform non-perturbative analysis of defect conformal field theory in 3D
The aggregation of the neuronal protein α-Synuclein is associated with the onset of Parkinson’s disease. Here the authors report a two-dimensional Fragment Assisted Structure-based technique to find antagonists of α-Synuclein aggregation and show its promise for identifying lead therapeutics for Parkinson’s disease.