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Neuronal activity in the secondary motor cortex of mice engaged in a foraging task simultaneously represents multiple alternative decision-making strategies.
Oxytocin-releasing projections from the paraventricular nucleus enhance top-down nociceptive regulation in rats by altering the excitation–inhibition balance in the prefrontal cortex.
The pathogenesis of multiple system atrophy, a rapidly progressing oligodendroglial α-synucleinopathy, is not well understood. In this Review, Stefanova and Wenning discuss how converging findings from genetic and neuropathological studies and experimental models have revealed a complex cascade of mechanisms that underlie the disorder.
Recent technological advances allow recordings of human brain activity to be made as participants engage in free movement inside and outside the laboratory. Suthana and colleagues describe these innovations, their application to cognitive neuroscience studies and their potential to transform our understanding of brain function in naturalistic settings.
Neural manifolds can shed light on how heterogeneous neuronal population activity drives neural computations, but linking these insights to the underlying neuronal connectivity is challenging. Engel and colleagues emphasize the importance of approaches that seek to connect neural dynamics with connectivity, providing key examples of advances towards this goal.
In many animals, injury can be followed by a pattern of persistent pain and recuperative behaviour that facilitates effective recovery. In this Perspective, Seymour, Crook and Chen outline a control theory framework to explain the adaptive processes that occur in the brain that underlie behaviour after injury.
