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An airway-to-brain sensory pathway mediates influenza-induced sickness
A small population of prostaglandin E2-responsive glossopharyngeal sensory neurons provides a sensory pathway between airway and brainstem that mediates sickness responses to early-phase influenza virus infection.
- Na-Ryum Bin
- , Sara L. Prescott
- & Stephen D. Liberles
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Article
| Open Access
A brainstem map for visceral sensations
In vivo two-photon calcium imaging analyses of sensory inputs from the gastrointestinal tract and upper airways in mice reveal spatial organization and coding principles of the interoceptive nervous system.
- Chen Ran
- , Jack C. Boettcher
- & Stephen D. Liberles
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Article
| Open Access
A multidimensional coding architecture of the vagal interoceptive system
Single-cell profiling of vagal sensory neurons from seven organs in mice and calcium-imaging-guided spatial transcriptomics reveal that interoceptive signals are coded through three distinct dimensions, allowing efficient processing of multiple signals in parallel using a combinatorial strategy.
- Qiancheng Zhao
- , Chuyue D. Yu
- & Rui B. Chang
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Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury
An epidural spinal cord stimulation system regulates blood pressure in the acute and chronic phases of spinal cord injury.
- Jordan W. Squair
- , Matthieu Gautier
- & Aaron A. Phillips
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A leptin–BDNF pathway regulating sympathetic innervation of adipose tissue
The authors show that leptin signalling regulates the plasticity of sympathetic architecture of adipose tissue via a top-down neural pathway that is crucial for energy homeostasis.
- Putianqi Wang
- , Ken H. Loh
- & Jeffrey Friedman
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Neuronal programming by microbiota regulates intestinal physiology
In a mouse model, aryl hydrocarbon receptor signalling in enteric neurons is revealed as a mechanism that helps to maintain gut homeostasis by integrating the luminal environment with the physiology of intestinal neural circuits.
- Yuuki Obata
- , Álvaro Castaño
- & Vassilis Pachnis
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Habenular TCF7L2 links nicotine addiction to diabetes
The transcription factor TCF7L2 mediates two important responses to nicotine in the medial habenula region of the rodent brain: aversion to nicotine, and regulation of blood sugar levels through a polysynaptic habenula–pancreas circuit.
- Alexander Duncan
- , Mary P. Heyer
- & Paul J. Kenny
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Innervation of thermogenic adipose tissue via a calsyntenin 3β–S100b axis
The newly identified calsyntenin 3β protein has a role in the innervation of thermogenic fat through a mechanism of communication—which is unique to mammals—between thermogenic adipocytes and sympathetic neurons.
- Xing Zeng
- , Mengchen Ye
- & Bruce M. Spiegelman
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Neuronal regulation of type 2 innate lymphoid cells via neuromedin U
Group 2 innate lymphoid cells express the neuromedin U receptor 1 (NMUR1) and respond to neuromedin U (NMU) released by adjacent enteric neurons, and this interaction results in an enhanced immediate early response to the nematode Nippostrongylus brasiliensis.
- Vânia Cardoso
- , Julie Chesné
- & Henrique Veiga-Fernandes
A vagal reflex evoked by airway closure