Peripheral nervous system articles within Nature

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  • Article
    | Open Access

    A specific neural reflex of the vagus nerve is identified that induces gasping in response to airway closure.

    • Michael S. Schappe
    • , Philip A. Brinn
    •  & Stephen D. Liberles

  • Article
    | Open Access

    The molecular mechanisms underlying the Bezold–Jarisch reflex and syncope (fainting) involve vagal sensory neurons that express neuropeptide Y receptor Y2, the deletion of which in animal models abolishes the Bezold–Jarisch reflex.

    • Jonathan W. Lovelace
    • , Jingrui Ma
    •  & Vineet Augustine

  • Article |

    A subpopulation of cholinergic neurons triggers Ca2+ currents among enterocytes to promote return to homeostasis after injury, and disruption of this process leads to gut inflammation and hyperplasia in Drosophila.

    • Afroditi Petsakou
    • , Yifang Liu
    •  & Norbert Perrimon

  • Article |

    Resident macrophages of the muscularis externa refine the enteric nervous system (ENS) early in life by pruning synapses and phagocytosing enteric neurons, and later switch to a neuro-supportive function, indicating that the ENS is governed by a dedicated population of resident macrophages that adapt to the timely needs of the ENS.

    • Maria Francesca Viola
    • , Marta Chavero-Pieres
    •  & Guy Boeckxstaens

  • Article
    | Open Access

    A small population of prostaglandin E2-responsive glossopharyngeal sensory neurons provides a sensory pathway between airway and brainstem that mediates sickness responses to early-phase influenza virus infection.

    • Na-Ryum Bin
    • , Sara L. Prescott
    •  & Stephen D. Liberles

  • Article
    | Open Access

    In vivo two-photon calcium imaging analyses of sensory inputs from the gastrointestinal tract and upper airways in mice reveal spatial organization and coding principles of the interoceptive nervous system.

    • Chen Ran
    • , Jack C. Boettcher
    •  & Stephen D. Liberles

  • Article
    | Open Access

    Experiments in mice show that the mechanically activated ion channel PIEZO1 is expressed in itch-specific sensory neurons and has a role in transducing mechanical itch.

    • Rose Z. Hill
    • , Meaghan C. Loud
    •  & Ardem Patapoutian

  • Article
    | Open Access

    Longitudinal imaging of nerve fibres in mice reveals that reinnervation after nerve injury can lead to neuropathic pain, which is mediated through aberrant patterns of reinnervation in denervated areas by nociceptors.

    • Vijayan Gangadharan
    • , Hongwei Zheng
    •  & Rohini Kuner

  • Article
    | Open Access

    Single-cell profiling of vagal sensory neurons from seven organs in mice and calcium-imaging-guided spatial transcriptomics reveal that interoceptive signals are coded through three distinct dimensions, allowing efficient processing of multiple signals in parallel using a combinatorial strategy.

    • Qiancheng Zhao
    • , Chuyue D. Yu
    •  & Rui B. Chang

  • Article |

    In a mouse model, aryl hydrocarbon receptor signalling in enteric neurons is revealed as a mechanism that helps to maintain gut homeostasis by integrating the luminal environment with the physiology of intestinal neural circuits.

    • Yuuki Obata
    • , Álvaro Castaño
    •  & Vassilis Pachnis

  • Article |

    The transcription factor TCF7L2 mediates two important responses to nicotine in the medial habenula region of the rodent brain: aversion to nicotine, and regulation of blood sugar levels through a polysynaptic habenula–pancreas circuit.

    • Alexander Duncan
    • , Mary P. Heyer
    •  & Paul J. Kenny

  • Letter |

    Three transient receptor potential channels (TRPA1, TRPV1 and TRPM3) mediate sensitivity to acute noxious heat in mice in a redundant system; mice lacking all three show severe deficits in heat sensing, whereas double-knockout mice do not.

    • Ine Vandewauw
    • , Katrien De Clercq
    •  & Thomas Voets

  • Letter |

    Group 2 innate lymphoid cells express the neuromedin U receptor 1 (NMUR1) and respond to neuromedin U (NMU) released by adjacent enteric neurons, and this interaction results in an enhanced immediate early response to the nematode Nippostrongylus brasiliensis.

    • Vânia Cardoso
    • , Julie Chesné
    •  & Henrique Veiga-Fernandes

  • Letter |

    The neuronal mechanism for the detection of non-painful warm stimuli has remained unclear; mammalian TRPM2 ion channel is shown to be required for warmth detection in the non-noxious range of 33–38 °C, and surprisingly to mediate responses to warmth in the autonomic nervous system.

    • Chun-Hsiang Tan
    •  & Peter A. McNaughton

  • Article |

    This study shows that nematodes without a germ line re-allocate resources to the soma, resulting in elevated proteasome activity, clearance of damaged proteins and increased longevity; this activity is associated with the increased expression of rpn-6 mediated by the transcription factor DAF-16.

    • David Vilchez
    • , Ianessa Morantte
    •  & Andrew Dillin

  • Article |

    Neurons of the peripheral nervous system need survival factors to prevent their death during development. Most in the central nervous system do not. Why are peripheral neurons so needy? Here it is shown that the neurotrophin receptors TrkA and TrkC, expressed at high levels by many peripheral nervous system neurons, behave as dependence receptors: they instruct neurons to die if there is no ligand around. By contrast, TrkB, expressed mainly in the central nervous system, does not signal death in the absence of ligand.

    • Vassiliki Nikoletopoulou
    • , Heiko Lickert
    •  & Yves-Alain Barde

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