Biomarkers articles within Polymer Journal

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• Original Article | 09 June 2022

  Synthesis of polycarbonates and polycarbonate/polyester copolymers through an ester-carbonate exchange reaction

  We describe the synthesis of polycarbonate (PC) by means of the polycondensation of diol formate and dialkyl carbonate through an ester-carbonate exchange reaction. Furthermore, the polycondensation of diol formate and diethyl carbonate in the presence of polyester (PEs) under reduced pressure affords a statistical copolymer of PC and PEs. The composition of PC and PEs in the copolymer can be arbitrarily altered by changing the feed ratio of the monomers to PEs.

  • Takayoshi Katoh
  • , Maai Saso
  •  & Tsutomu Yokozawa

• Original Article | 18 June 2019

  Polymeric water-soluble activated esters: synthesis of polymer backbones with pendant N-hydoxysulfosuccinimide esters for post-polymerization modification in water

  Novel polymer backbones with pendant water-soluble activated esters were synthesized by a reversible addition-fragmentation chain transfer (RAFT) polymerization technique using an acrylamide derivative  bearing an N-hydroxysulfosuccinimide (sulfoNHS) ester as a monomer substrate. To synthesize glycopolymers, the substitution reaction at the sulfoNHS esters on the polymer side chain with an amine-containing saccharide derivative was performed in water. The resulting glycopolymer exhibited a strong interaction with the corresponding lectin in aqueous solution, because the saccharide moieties are multivalent.

  • Sotaro Tsuji
  • , Yuji Aso
  •  & Tomonari Tanaka

• Original Article | 22 March 2018

  Responsibility of lipid compositions for the amyloid ß assembly induced by ganglioside nanoclusters in mouse synaptosomal membranes

  Amyloid ß-protein (Aß) is converted to toxic forms through interactions with the ganglioside in neuronal membranes. The highly ganglioside-enriched microdomain (ganglioside cluster) in neuronal membranes plays a key role in Aß assembly. In the present study, lipid components of synaptosome extracted from mouse aged brain was determined by LC-MS spectroscopy. We demonstrated that ganglioside ratio (GM3 to GM1) and cholesterol content are an important factor for inducing Aß assembly. These results provides important insight into the mechanism of polypeptide assembly on the neuronal membrane in Alzheimer’s disease patients.

  • Teruhiko Matsubara
  • , Takahiro Kojima
  •  & Toshinori Sato