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Programming multicellular assembly with synthetic cell adhesion molecules
Synthetic cell adhesion molecules yield customized cell–cell interactions with adhesion properties that are similar to native interactions, and offer abilities for cell and tissue engineering and for systematically studying multicellular organization.
- Adam J. Stevens
- , Andrew R. Harris
- & Wendell A. Lim
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Letter |
A non-canonical Notch complex regulates adherens junctions and vascular barrier function
The transmembrane domain of NOTCH1 plays a key role in the assembly of adherens junctions and the non-transcriptional regulation of vascular permeability that links transcriptional programs with adhesive and cytoskeletal remodelling.
- William J. Polacheck
- , Matthew L. Kutys
- & Christopher S. Chen
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Letter |
Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction
A combination of structural, computational and biophysical tools is used to characterize the bond between tip-link proteins protocadherin 15 and cadherin 23, which have an essential role in inner-ear mechanotransduction; the bond, involving an extended protein handshake, is found to be affected by deafness mutations and is mechanically strong enough to resist forces in hair cells, adding to our understanding of hair-cell sensory transduction and interactions among cadherins.
- Marcos Sotomayor
- , Wilhelm A. Weihofen
- & David P. Corey
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Letter |
Protocadherins mediate dendritic self-avoidance in the mammalian nervous system
Protocadherins are found to potentially provide the molecular diversity and complexity required to promote dendritic self-avoidance in mouse retina and cerebellum.
- Julie L. Lefebvre
- , Dimitar Kostadinov
- & Joshua R. Sanes
Mechanics of human embryo compaction