Carbohydrate chemistry articles within Nature

Featured

• Article | 16 June 2022

  Site-selective, stereocontrolled glycosylation of minimally protected sugars

  A simplified synthesis strategy for stereo- and site-selective glycosylations, using minimally protected mono- and disaccharides and thiourea small-molecule catalysts, enables highly selective functionalization of carbohydrates.

  • Qiuhan Li
  • , Samuel M. Levi
  •  & Eric N. Jacobsen

• Article | 29 July 2020

  Lysosome-targeting chimaeras for degradation of extracellular proteins

  Lysosome-targeting chimaeras—in which a small molecule or antibody is connected to a glycopeptide ligand to form a conjugate that can bind a cell-surface lysosome-shuttling receptor and a protein target—are used to achieve the targeted degradation of extracellular and membrane proteins.

  • Steven M. Banik
  • , Kayvon Pedram
  •  & Carolyn R. Bertozzi

• Article | 15 January 2020

  Synthesis of rare sugar isomers through site-selective epimerization

  Various rare sugars that cannot be isolated from natural sources are synthesized using light-driven epimerization, a process which may find application in other synthetic scenarios.

  • Yong Wang
  • , Hayden M. Carder
  •  & Alison E. Wendlandt

• Letter | 30 September 2015

  Identification of carbohydrate anomers using ion mobility–mass spectrometry

  The branched structure and stereoisomerism of carbohydrates make them difficult to analyse; here, ion mobility–mass spectrometry is used to distinguish unambiguously between synthetic trisaccharides that differ in connectivity or configuration.

  • J. Hofmann
  • , H. S. Hahm
  •  & K. Pagel