Article
|
Open Access
Featured
-
-
Letter |
Mechanosensing by β1 integrin induces angiocrine signals for liver growth and survival
In mouse and human liver models, blood vessel perfusion and mechanical stretching release angiocrine signals from endothelial cells that lead to hepatocyte survival and liver growth.
- Linda Lorenz
- , Jennifer Axnick
- & Eckhard Lammert
-
Letter |
Programmable single-cell mammalian biocomputers
In synthetic biology, the use of regulatory proteins that bind either DNA or RNA to reprogram mammalian cellular functions allows a variety of computational ‘logic circuits’ to be built in a plug-and-play manner, which may pave the way for precise and robust control of future gene-based and cell-based therapies.
- Simon Ausländer
- , David Ausländer
- & Martin Fussenegger
-
News |
Regenerative medicine repairs mice from top to toe
Three separate studies in mice show normal function can be restored to hair, eye and heart cells.
- Leila Haghighat
-
Letter |
Clusters of iron-rich cells in the upper beak of pigeons are macrophages not magnetosensitive neurons
Birds have been thought to have a magnetic sensing system consisting of magnetite-containing dendrites in the upper beak; a comprehensive anatomical characterization in pigeons now shows that the iron-rich cells in the beak are in fact macrophages not magnetosensitive neurons.
- Christoph Daniel Treiber
- , Marion Claudia Salzer
- & David Anthony Keays
-
Research Highlights |
James Crow on sabotaging sperm
-
Research Highlights |
Sperm steer with calcium
-
News Feature |
Cell biology: The new cell anatomy
A menagerie of intriguing cell structures, some long-neglected and others newly discovered, is keeping biologists glued to their microscopes.
- Roberta Kwok
-
Research Highlights |
Fat fuels abdominal cancers
-
Article |
Human oocytes reprogram somatic cells to a pluripotent state
- Scott Noggle
- , Ho-Lim Fung
- & Dieter Egli
-
Letter |
The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes
- Tian-Peng Gu
- , Fan Guo
- & Guo-Liang Xu
-
Letter |
Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein
- Kasia Hrecka
- , Caili Hao
- & Jacek Skowronski
-
Letter |
Progesterone activates the principal Ca2+ channel of human sperm
Progesterone stimulates an increase in Ca2+ levels in human sperm, but the underlying signalling mechanism is poorly understood. Two studies now show that progesterone activates the sperm-specific, pH-sensitive CatSper calcium channel, leading to a rapid influx of Ca2+ ions into the spermatozoa. These results should help to define the physiological role of progesterone and CatSper in sperm, and could lead to the development of new classes of non-hormonal contraceptives.
- Polina V. Lishko
- , Inna L. Botchkina
- & Yuriy Kirichok
-
Research Highlights |
Tagging the TB bacterium
-
News |
Of femurs and fertility
Mouse studies suggest bone hormone affects male fertility.
- Tiffany O'Callaghan
-
Research Highlights |
Fooling the heart into repair
-
Research Highlights |
The many styles of sperm
-
Letter |
Unexpected requirement for ELMO1 in clearance of apoptotic germ cells in vivo
Cell death by apoptosis is crucial for tissue development and function, and occurs throughout life. Apoptotic cells must be cleared by phagocytic cells, but the mechanisms that regulate cell clearance in vivo remain unclear. Here, a conserved engulfment protein, ELMO1, is shown to be required for the phagocytic clearance of apoptotic germ cells by Sertoli cells in mouse testes. The findings make a compelling case for the relationship between engulfment and tissue homeostasis in vivo.
- Michael R. Elliott
- , Shuqiu Zheng
- & Kodi S. Ravichandran
-
News & Views |
Bridges that guide and unite
To form new blood vessels, the endothelial tip cells of two existing vessels come together by the process of anastomosis. But how do they find each other? Macrophages seem to provide a bridge and mediate their union.
- Thomas Schmidt
- & Peter Carmeliet
-
News |
Freeing human eggs of mutant mitochondria
Transmission of mitochondrial diseases from mother to offspring could be prevented.
- Alla Katsnelson
-
News & Views |
Random expression goes binary
The production of intestinal cells in a worm embryo is regulated by a network of transcription factors. Studies of these networks in mutant worms provide evidence for stochastic effects in gene expression.
- Adrian Streit
- & Ralf J. Sommer
-
News |
How accurate are cancer cell lines?
Some argue that tumour cells obtained directly from patients are the best way to study cancer genomics.
- Brendan Borrell
-
Research Highlights |
Imaging: Virus vision
-
Books & Arts |
The woman behind HeLa
Steve Silberman enjoys a moving account that probes racial and ethical issues in medicine through the story of the young mother whose death from cancer led to the first immortal cell line.
- Steve Silberman
-
-
Letter |
Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency
The extent of epigenetic reprogramming in mammalian primordial germ cells (PGCs) and in early embryos, and its molecular mechanisms, are poorly understood. DNA methylation profiling in PGCs now reveals a genome–wide erasure of methylation, with female PGCs being less methylated than male ones. A deficiency of the cytidine deaminase AID interferes with the genome–wide erasure of DNA methylation, indicating that AID has a critical function in epigenetic reprogramming.
- Christian Popp
- , Wendy Dean
- & Wolf Reik
-
News |
Brother sperm train together
Mouse sperm cells team up with their kin in the race to fertilize eggs.
- John Whitfield
-
Letter |
Competition drives cooperation among closely related sperm of deer mice
Sperm can increase their swimming velocity and gain a competitive advantage over sperm from another male by forming cooperative groups, such that selection should favour cooperation of the most closely related sperm. Sperm of deer mice are now shown to aggregate more often with conspecific than heterospecific sperm, in accordance with this theory, whereas in a monogamous species lacking sperm competition, sperm indiscriminately group with unrelated conspecific sperm.
- Heidi S. Fisher
- & Hopi E. Hoekstra