Research Highlights |
Featured
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Research Highlights |
Sperm steer with calcium
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Article |
Human oocytes reprogram somatic cells to a pluripotent state
- Scott Noggle
- , Ho-Lim Fung
- & Dieter Egli
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Letter |
The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes
- Tian-Peng Gu
- , Fan Guo
- & Guo-Liang Xu
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Letter |
Progesterone activates the principal Ca2+ channel of human sperm
Progesterone stimulates an increase in Ca2+ levels in human sperm, but the underlying signalling mechanism is poorly understood. Two studies now show that progesterone activates the sperm-specific, pH-sensitive CatSper calcium channel, leading to a rapid influx of Ca2+ ions into the spermatozoa. These results should help to define the physiological role of progesterone and CatSper in sperm, and could lead to the development of new classes of non-hormonal contraceptives.
- Polina V. Lishko
- , Inna L. Botchkina
- & Yuriy Kirichok
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Research Highlights |
The many styles of sperm
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Letter |
Unexpected requirement for ELMO1 in clearance of apoptotic germ cells in vivo
Cell death by apoptosis is crucial for tissue development and function, and occurs throughout life. Apoptotic cells must be cleared by phagocytic cells, but the mechanisms that regulate cell clearance in vivo remain unclear. Here, a conserved engulfment protein, ELMO1, is shown to be required for the phagocytic clearance of apoptotic germ cells by Sertoli cells in mouse testes. The findings make a compelling case for the relationship between engulfment and tissue homeostasis in vivo.
- Michael R. Elliott
- , Shuqiu Zheng
- & Kodi S. Ravichandran
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News |
Freeing human eggs of mutant mitochondria
Transmission of mitochondrial diseases from mother to offspring could be prevented.
- Alla Katsnelson
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Letter |
Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency
The extent of epigenetic reprogramming in mammalian primordial germ cells (PGCs) and in early embryos, and its molecular mechanisms, are poorly understood. DNA methylation profiling in PGCs now reveals a genome–wide erasure of methylation, with female PGCs being less methylated than male ones. A deficiency of the cytidine deaminase AID interferes with the genome–wide erasure of DNA methylation, indicating that AID has a critical function in epigenetic reprogramming.
- Christian Popp
- , Wendy Dean
- & Wolf Reik
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News |
Brother sperm train together
Mouse sperm cells team up with their kin in the race to fertilize eggs.
- John Whitfield
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Letter |
Competition drives cooperation among closely related sperm of deer mice
Sperm can increase their swimming velocity and gain a competitive advantage over sperm from another male by forming cooperative groups, such that selection should favour cooperation of the most closely related sperm. Sperm of deer mice are now shown to aggregate more often with conspecific than heterospecific sperm, in accordance with this theory, whereas in a monogamous species lacking sperm competition, sperm indiscriminately group with unrelated conspecific sperm.
- Heidi S. Fisher
- & Hopi E. Hoekstra