Chemical libraries articles within Nature

Featured

• Article | 29 March 2023

  Mechanistic formulation of inorganic membranes at the air–liquid interface

  By switching the nucleation preferences in aqueous systems of inorganic precursors to bias formation and growth at the air–liquid interface, the mechanistic formation of inorganic membranes from the floating-particle system is demonstrated.

  • Chen Zhang
  • , Wanheng Lu
  •  & Ghim Wei Ho

• Article | 14 February 2022

  Synthesis of chiral sulfinate esters by asymmetric condensation

  A synthetic strategy for the stereoselective preparation of sulfinate esters and related sulfur stereogenic centres via asymmetric condensation expands the drug discovery toolbox for these compounds.

  • Xin Zhang
  • , Esther Cai Xia Ang
  •  & Choon-Hong Tan

• Article | 10 February 2020

  Virtual discovery of melatonin receptor ligands to modulate circadian rhythms

  A computational screen of an ultra-large virtual library against the structure of the melatonin receptor found nanomolar ligands, and ultimately two selective MT₁ inverse agonists that induced phase advancement of the mouse circadian clock when given at subjective dusk.

  • Reed M. Stein
  • , Hye Jin Kang
  •  & Margarita L. Dubocovich

• Letter | 02 October 2019

  Modular click chemistry libraries for functional screens using a diazotizing reagent

  A ‘click’ reaction is developed for the simple and rapid formation of azides from primary amines, and is used to prepare a library of over 1,200 azides for subsequent use in the existing triazole annulation click reaction.

  • Genyi Meng
  • , Taijie Guo
  •  & Jiajia Dong

• Article | 06 February 2019

  Ultra-large library docking for discovering new chemotypes

  Using a make-on-demand library that contains hundreds-of-millions of molecules, structure-based docking was used to identify compounds that, after synthesis and testing, are shown to interact with AmpC β-lactamase and the D₄ dopamine receptor with high affinity.

  • Jiankun Lyu
  • , Sheng Wang
  •  & John J. Irwin

• News & Views Forum | 02 February 2011

  A question of library design

  Two approaches have emerged for creating libraries of compounds for use in biological screening assays for drug discovery — fragment-based ligand design and diversity-oriented synthesis. Advocates of each approach discuss their favoured strategy.

  • Philip J. Hajduk
  • , Warren R. J. D. Galloway
  •  & David R. Spring

• News & Views | 10 March 2010

  Sticking to sugars

  If evolution has had trouble making effective carbohydrate receptors, what hope do humans have of creating synthetic versions? A method for preparing libraries of such receptors boosts the chances of success.

  • Anthony P. Davis