Combinatorial libraries articles within Nature

Featured

• Article
  05 December 2023 | Open Access

  Reverse metabolomics for the discovery of chemical structures from humans

  A new discovery strategy, ‘reverse metabolomics’, facilitates high-throughput matching of mass spectrometry spectra in public untargeted metabolomics datasets, and a proof-of-concept experiment identified an association between microbial bile amidates and inflammatory bowel disease.

  • Emily C. Gentry
  • , Stephanie L. Collins
  •  & Pieter C. Dorrestein

• Article | 01 April 2020

  A map of the amine–carboxylic acid coupling system

  All possible chemical transformations between amine and carboxylic acid groups are mapped using an automated string-based combinatorics method, showing that the properties and functions of the products vary considerably over all plausible reactions.

  • Babak Mahjour
  • , Yuning Shen
  •  & Tim Cernak

• Letter | 02 October 2019

  Modular click chemistry libraries for functional screens using a diazotizing reagent

  A ‘click’ reaction is developed for the simple and rapid formation of azides from primary amines, and is used to prepare a library of over 1,200 azides for subsequent use in the existing triazole annulation click reaction.

  • Genyi Meng
  • , Taijie Guo
  •  & Jiajia Dong

• Letter | 23 April 2018

  Nanoscale synthesis and affinity ranking

  A system that combines nanoscale synthesis and affinity ranking enables high-throughput screening of reaction conditions and bioactivity for a given protein target, accelerating the process of drug discovery.

  • Nathan J. Gesmundo
  • , Bérengère Sauvagnat
  •  & Tim Cernak