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Prefrontal feature representations drive memory recall
Longitudinal imaging and functional perturbations during behaviour identified a brain region that represents constituent features of a contextual memory and enables feature-mediated memory recall.
- Nakul Yadav
- , Chelsea Noble
- & Priyamvada Rajasethupathy
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Differential mechanisms underlie trace and delay conditioning in Drosophila
Trace and delay conditioning experiments in Drosophila reveal the different neurons and signalling mechanisms that underlie this behaviour and highlight similarities with observations of learning experiences in mammals.
- Dhruv Grover
- , Jen-Yung Chen
- & Ralph J. Greenspan
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A speech planning network for interactive language use
Using intracranial electrocorticography and a series of motor tasks, a speech planning network that is central to natural language generation during social interaction is identified.
- Gregg A. Castellucci
- , Christopher K. Kovach
- & Michael A. Long
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Article
| Open Access
Thalamic circuits for independent control of prefrontal signal and noise
Two different cell types in the mediodorsal thalamus have complementary roles in decision-making, with one type of mediodorsal projection amplifying prefrontal activity under low signal levels and one type suppressing it under high noise levels.
- Arghya Mukherjee
- , Norman H. Lam
- & Michael M. Halassa
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Shared mechanisms underlie the control of working memory and attention
The prefrontal cortex in monkeys controls working memory in a similar way to attention, by selectively transforming the representations of remembered items.
- Matthew F. Panichello
- & Timothy J. Buschman
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Reset of hippocampal–prefrontal circuitry facilitates learning
Exposure to a novel experience can ‘reset’ connections between the hippocampus and prefrontal cortex in mice, allowing them to overcome an existing learned behaviour and to replace it with a new one.
- Alan J. Park
- , Alexander Z. Harris
- & Joshua A. Gordon
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eIF2α controls memory consolidation via excitatory and somatostatin neurons
Stimulation of de novo protein synthesis in both excitatory and inhibitory, somatostatin-expressing neurons in the mouse hippocampus enhances memory consolidation.
- Vijendra Sharma
- , Rapita Sood
- & Nahum Sonenberg
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Thalamic amplification of cortical connectivity sustains attentional control
The mediodorsal nucleus of the thalamus amplifies the functional connectivity of the prefrontal cortex, thereby sustaining cortical representations of rule sets without relaying categorical information.
- L. Ian Schmitt
- , Ralf D. Wimmer
- & Michael M. Halassa
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Letter |
Gamma oscillations organize top-down signalling to hypothalamus and enable food seeking
Coordinated gamma oscillations in the lateral hypothalamus, lateral septum and medial prefrontal cortex are shown to drive food-seeking behaviour in mice independently of nutritional need and to organize firing of feeding behaviour-related hypothalamic neurons.
- Marta Carus-Cadavieco
- , Maria Gorbati
- & Tatiana Korotkova
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Letter |
Video game training enhances cognitive control in older adults
Training with a multitasking video game is shown to improve cognitive control abilities that decline with age, revealing the plasticity of the ageing brain; these behavioural improvements were accompanied by underlying neural changes that predicted the training-induced boost in sustained attention and enhanced multitasking performance 6 months later.
- J. A. Anguera
- , J. Boccanfuso
- & A. Gazzaley
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The importance of mixed selectivity in complex cognitive tasks
When an animal is performing a cognitive task, individual neurons in the prefrontal cortex show a mixture of responses that is often difficult to decipher and interpret; here new computational methods to decode and extract rich sets of information from these neural responses are revealed and demonstrate how this mixed selectivity offers a computational advantage over specialized cells.
- Mattia Rigotti
- , Omri Barak
- & Stefano Fusi
A somato-cognitive action network alternates with effector regions in motor cortex