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Article
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Structural basis of gating modulation of Kv4 channel complexes
Cryo-electron microscopy structures of the voltage-gated potassium channel Kv4.2 alone and in complex with auxiliary subunits (DPP6S and/or KChIP1) reveal the distinct mechanisms of these two different subunits in modulating channel activity.
- Yoshiaki Kise
- , Go Kasuya
- & Osamu Nureki
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Letter |
Fully integrated silicon probes for high-density recording of neural activity
New silicon probes known as Neuropixels are shown to record from hundreds of neurons simultaneously in awake and freely moving rodents.
- James J. Jun
- , Nicholas A. Steinmetz
- & Timothy D. Harris
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Letter |
Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3
A cryo-electron microscopy structure shows that the mucolipin domain of the lysosomal calcium channel TRPML3 binds phosphatidylinositol-3,5-bisphosphate and gates the channel.
- Marscha Hirschi
- , Mark A. Herzik Jr
- & Seok-Yong Lee
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Outlook |
Technology: Dressed to detect
Wearable devices that monitor seizures promise improvements in epilepsy treatments and research.
- Elie Dolgin
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Article |
Gating of the TrkH ion channel by its associated RCK protein TrkA
Here it is shown that ion flux through the TrkH–TrkA complex is upregulated by ATP and downregulated by ADP; solving the X-ray crystal structures of the tetrameric TrkA ring in the absence and presence of TrkH suggests a mechanism by which ATP-induced conformational changes in TrkA augment the activity of TrkH.
- Yu Cao
- , Yaping Pan
- & Ming Zhou
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Outlook |
Diagnostics: The new risk predictors
New imaging methods and biomarkers may help identify people who are at risk for heart disease but are overlooked by standard risk assessments.
- Peter Gwynne
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Outlook |
Physiology: Beating stroke
New drugs and more focused therapy might cut down on atrial fibrillation and reduce the incidence of stroke.
- Neil Savage
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Research Highlights |
Faces warp as brain area is zapped
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News |
Seizure detector treats epilepsy in rats
Minimally invasive brain stimulator reduces duration of seizures.
- Duncan Graham-Rowe
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Letter |
Theta-paced flickering between place-cell maps in the hippocampus
- Karel Jezek
- , Espen J. Henriksen
- & May-Britt Moser
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Research Highlights |
Skin-deep electronics
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News |
A kinder, gentler defibrillator
A new technique could lower the intensity of the shock needed to reset electrical instabilities in the heart.
- Alla Katsnelson
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Letter |
Ultra-prolonged activation of CO2-sensing neurons disorients mosquitoes
- Stephanie Lynn Turner
- , Nan Li
- & Anandasankar Ray
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Letter |
Tunable pKa values and the basis of opposite charge selectivities in nicotinic-type receptors
- Gisela D. Cymes
- & Claudio Grosman
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Research Highlights |
Animal behaviour: Lobster shock
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Review Article |
Measurement of single-cell dynamics
- David G. Spiller
- , Christopher D. Wood
- & Michael R. H. White
Single-neuronal elements of speech production in humans
Local sleep in awake rats