Feeding behaviour articles within Nature

Featured

  • Article
    | Open Access

    In response to acute thermal challenge, thermosensing glutamatergic neurons of the parabrachial nucleus in mouse brain activate tanycytes, which reduce the excitability of Flt1-expressing dopamine and agouti-related peptide-containing neurons, thus suppressing appetite.

    • Marco Benevento
    • , Alán Alpár
    •  & Tibor Harkany

  • Article
    | Open Access

    An appetite-regulating subnetwork in humans involving the lateral hypothalamus and the dorsolateral hippocampus is implicated in obesity and related eating disorders.

    • Daniel A. N. Barbosa
    • , Sandra Gattas
    •  & Casey H. Halpern

  • Article
    | Open Access

    Through leverage of whole-brain screening, in vivo calcium imaging and chemo- and optogenetic manipulations, it is demonstrated that the xiphoid nucleus serves as a key brain region in the promotion of cold-induced food-seeking behaviours.

    • Neeraj K. Lal
    • , Phuong Le
    •  & Li Ye

  • Article
    | Open Access

    Mast cells are shown to function as sensor cells linking antigen recognition in type 2 immunity to antigen-specific avoidance behaviour, preventing immune activation and inflammation.

    • Thomas Plum
    • , Rebecca Binzberger
    •  & Hans-Reimer Rodewald

  • Article
    | Open Access

    A studying using a set of unbiased methodologies shows that a specific subpopulation of neurons in the brainstem can regulate the diverse responses to a bacterial endotoxin that induces sickness behaviours.

    • Anoj Ilanges
    • , Rani Shiao
    •  & Jeffrey M. Friedman

  • Article |

    Fruitflies require Sestrin to regulate mTORC1 signalling in response to dietary leucine, survive a diet low in leucine, and control leucine-sensitive physiological characteristics, which establishes Sestrin as a physiologically relevant leucine sensor.

    • Xin Gu
    • , Patrick Jouandin
    •  & David M. Sabatini

  • Article
    | Open Access

    Distinct dopaminergic neurons in the ventral tegmental area respond to physiological fluid balance and nutrient cues at specific stages of ingestion, driving learning about the physiological effects of ingestion.

    • James C. R. Grove
    • , Lindsay A. Gray
    •  & Zachary A. Knight

  • Article |

    High-resolution volumetric calcium imaging was used to create a functional atlas of the Drosophila melanogaster ventral brain and identify how and where metabolic and reproductive states alter processing of food-related sensory stimuli.

    • Daniel Münch
    • , Dennis Goldschmidt
    •  & Carlos Ribeiro

  • Article |

    Activity in anterior deep cerebellar nuclei reduces food consumption in mice without reducing metabolic rate, potentially identifying a therapeutic target for disorders involving excessive eating.

    • Aloysius Y. T. Low
    • , Nitsan Goldstein
    •  & J. Nicholas Betley

  • Article |

    In response to food cues, a hypothalamic circuit in the mouse brain transiently inhibits neurons expressing agouti-related peptide, and this promotes learning of cue-initiated food-seeking tasks.

    • Janet Berrios
    • , Chia Li
    •  & Bradford B. Lowell

  • Article |

    The authors uncover the diverse transcriptomic cell types of thirst-driving neurons in the lamina terminalis and show that unique combinations of neuron types respond to and mediate distinct thirst states.

    • Allan-Hermann Pool
    • , Tongtong Wang
    •  & Yuki Oka

  • Article |

    A specific neuronal population in the medial and lateral preoptic area of the hypothalamus regulates entry into torpor in mice.

    • Sinisa Hrvatin
    • , Senmiao Sun
    •  & Michael E. Greenberg

  • Article |

    A population of neurons in the parabrachial nucleus that expresses prodynorphin monitors ingestion using mechanosensory signals from the upper digestive tract, and mediates negative feedback control of intake when the digestive tract is distended.

    • Dong-Yoon Kim
    • , Gyuryang Heo
    •  & Sung-Yon Kim

  • Article |

    A pair of glucose-sensing neurons identified in the brain of Drosophila melanogaster regulates secretion of adipokinetic hormone and Drosophila insulin-like peptide 2, suggesting that these neurons have key roles in maintenance of glucose homeostasis.

    • Yangkyun Oh
    • , Jason Sih-Yu Lai
    •  & Greg S. B. Suh

  • Letter |

    Drinking behaviour in mice is regulated by a signal derived from the water and salt content of the gastrointestinal tract that is transmitted to forebrain neurons that control thirst via the vagus nerve.

    • Christopher A. Zimmerman
    • , Erica L. Huey
    •  & Zachary A. Knight

  • Article |

    Single-cell recordings show that CGRP-expressing neurons in the parabrachial nucleus in mice respond to both noxious stimuli and signals of feeding satiety.

    • Carlos A. Campos
    • , Anna J. Bowen
    •  & Richard D. Palmiter

  • Outline |

    Increased levels of obesity are driving an epidemic of non-alcoholic fatty liver disease. Understanding, diagnosing and treating this progressive condition are now priorities.

    • Liam Drew

  • Outline |

    A progressive and potentially life-threatening condition previously associated with alcoholism is becoming more common — even in non-drinkers.

    • Liam Drew

  • Article |

    A combination of microprism-based cellular imaging to monitor insular cortex visual cue responses in behaving mice across hunger states with circuit mapping and manipulations reveals a neural basis for state-specific biased processing of motivationally relevant cues.

    • Yoav Livneh
    • , Rohan N. Ramesh
    •  & Mark L. Andermann

  • Article |

    Osteoblast-derived LCN2 activates the melanocortin 4 receptor in neurons of the paraventricular nucleus of the hypothalamus to suppress appetite, regulates insulin secretion and increases insulin sensitivity and glucose tolerance.

    • Ioanna Mosialou
    • , Steven Shikhel
    •  & Stavroula Kousteni

  • Letter |

    A mouse study reveals that acetylcholine signalling networks have a role in the regulation of body weight homeostasis, with increased activity of cholinergic neurons decreasing food consumption through downstream hypothalamic targets.

    • Alexander M. Herman
    • , Joshua Ortiz-Guzman
    •  & Benjamin R. Arenkiel

  • Letter |

    Feedback from the oral cavity to thirst-promoting neurons in the subfornical organ (SFO) during eating and drinking is integrated with information about blood composition, providing a prediction of how oral consumption will affect fluid balance and leading to changes in behaviour.

    • Christopher A. Zimmerman
    • , Yen-Chu Lin
    •  & Zachary A. Knight

  • Letter |

    Activation of glucose-sensing neurons in the ventromedial hypothalamic nucleus using radio waves or magnetic fields remotely and non-invasively in vivo increases plasma glucose and glucagon, and suppresses plasma insulin; conversely, remote inhibition of glucose-sensing neurons decreased blood glucose and increased plasma insulin.

    • Sarah A. Stanley
    • , Leah Kelly
    •  & Jeffrey M. Friedman

  • Article |

    Cell-type-specific electrical activity manipulations and deep-brain imaging in mice of neuronal populations associated with homeostasis of nutrient or fluid intake reveals that learning is conditioned by a negative-valence signal from the hunger-mediating AGRP neurons and also from the thirst-mediating neurons in the subfornical organ.

    • J. Nicholas Betley
    • , Shengjin Xu
    •  & Scott M. Sternson

  • Article |

    Cannabinoid-induced feeding signals are shown to enhance pro-opiomelanocortin (POMC) neuronal activity in mice, causing an enhancement of β-endorphin release, which is crucial in causing this cannabinoid-induced response; these results uncover an overlooked role of hypothalamic POMC neurons in the promotion of feeding by cannabinoids.

    • Marco Koch
    • , Luis Varela
    •  & Tamas L. Horvath

  • Letter |

    α-MSH and AgRP, two hypothalamus-derived peptides with opposing actions on the melanocortin-4 receptor (MC4R), modulate neurons driving feeding behaviour; although previous downstream mechanisms of cellular modulation by these peptides have been determined, here α-MSH and AgRP are shown to regulate neural activity by coupling MC4R to Kir7.1 potassium channels and closing or opening them, respectively.

    • Masoud Ghamari-Langroudi
    • , Gregory J. Digby
    •  & Roger D. Cone

  • Outlook |

    • Tony Scully

  • Outlook |

    Processed foods that dilute protein content subvert our appetite control systems, say Stephen J. Simpson and David Raubenheimer.

    • Stephen J. Simpson
    •  & David Raubenheimer

  • Outlook |

    A slew of new technologies are helping to map the neural circuits that control when, and how much, we eat.

    • Bijal P. Trivedi

  • Letter |

    The AgRP-expressing neurons in the arcuate nucleus drive food-seeking behaviours during caloric restriction; a mouse study of monosynaptic retrograde rabies spread and optogenetic circuit mapping reveals that these neurons are activated by input from hypothalamic paraventricular nucleus cells and their activation or inhibition can modulate feeding behaviour.

    • Michael J. Krashes
    • , Bhavik P. Shah
    •  & Bradford B. Lowell

  • Outlook |

    A growing body of evidence shows that getting a good night's sleep plays an important role in regulating the body's metabolism.

    • Brian Owens

  • Outlook |

    It is becoming clear that links between taste preferences and obesity go beyond simply having a sweet tooth.

    • James Mitchell Crow

  • Editorial |

    A previously unknown sensory organ provides a lesson in coordination.

  • News & Views |

    A specialist neuron uses an intriguing process to help control the body's response to hunger. A lipid pathway involving the breakdown of cellular components regulates the expression of a neuropeptide that affects feeding and body weight.

    • Scott M. Sternson

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