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| Open AccessMsx1+ stem cells recruited by bioactive tissue engineering graft for bone regeneration
Critical-sized bone defects still present clinical challenges. Here the authors show that transplantation of neurotrophic supplement-incorporated hydrogel grafts promote full-thickness regeneration of the calvarium and perform scRNA-seq to reveal contributing stem/progenitor cells, notably a resident Msx1+ skeletal stem cell population.
- Xianzhu Zhang
- , Wei Jiang
- & Hongwei Ouyang
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| Open AccessAlloying design of biodegradable zinc as promising bone implants for load-bearing applications
Biodegradable implants are of great interest in orthopaedic applications but have been limited by low mechanical strength. Here, the authors examine systematically in detail the strengthening of biodegradable zinc by alloying with beneficial elements using mechanical, biodegradability and biocompatibility testing.
- Hongtao Yang
- , Bo Jia
- & Yufeng Zheng
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| Open AccessA bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair
Antibodies that block the Wnt inhibitors sclerostin and DKK- 1 enhance bone formation and fracture repair. Here the authors show these monospecific antibodies induce compensatory mechanisms that limit efficacy, and have designed a sclerostin/DKK-1 bispecific antibody that promotes superior fracture repair in rodents and bone formation in primates.
- Monica Florio
- , Kannan Gunasekaran
- & Michael S. Ominsky
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| Open AccessIL-17-producing γδ T cells enhance bone regeneration
γδ T cells are innate-like lymphocytes that regulate immune responses by producing IL-17A or IFN-γ, but have no known role in bone healing. Here the authors show a nonimmune bone-regenerative function of IL-17A produced by the Vγ6+ subset in mice.
- Takehito Ono
- , Kazuo Okamoto
- & Hiroshi Takayanagi
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| Open AccessExposure to a youthful circulation rejuvenates bone repair through modulation of β-catenin
The reparative capacity of tissues decreases with age. Here, Baht et al. perform parabiosis experiments and provide evidence for the existence of a soluble factor produced by young, but not old, haematopoietic cells that is capable of improving fracture repair in old mice.
- Gurpreet S. Baht
- , David Silkstone
- & Benjamin A. Alman