Haematopoietic system articles within Nature

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• Article
  20 March 2024 | Open Access

  Resilient anatomy and local plasticity of naive and stress haematopoiesis

  This study develops a method for spatially resolving multipotent haematopoiesis, erythropoiesis and lymphopoiesis in mice and uncovers heterogeneous haematopoietic stress responses in different bones.

  • Qingqing Wu
  • , Jizhou Zhang
  •  & Daniel Lucas

• Article | 20 November 2019

  Genetic predisposition to mosaic Y chromosome loss in blood

  A genome-wide association study of mosaic loss of chromosome Y (LOY) in UK Biobank participants identifies 156 genetic determinants of LOY, showing that LOY is associated with cancer and non-haematological health outcomes.

  • Deborah J. Thompson
  • , Giulio Genovese
  •  & John R. B. Perry

• Article | 21 March 2010

  Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia

  A new mouse model is developed in which haematopoietic malignancies are caused by genetic changes in the microenvironment of blood cells. Deletion in bone progenitor cells of Dicer1, a gene involved in microRNA processing, leads to a myelodysplastic syndrome-like phenotype which can progress to leukaemia. Deregulation of Sbds, which is mutated in human Schwachman–Bodian–Diamond syndrome, may be involved in this process.

  • Marc H. G. P. Raaijmakers
  • , Siddhartha Mukherjee
  •  & David. T. Scadden