Haemic and immune systems articles within Nature

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  • Article |

    A genome-wide association study of mosaic loss of chromosome Y (LOY) in UK Biobank participants identifies 156 genetic determinants of LOY, showing that LOY is associated with cancer and non-haematological health outcomes.

    • Deborah J. Thompson
    • , Giulio Genovese
    •  & John R. B. Perry

  • Outlook |

    Increased understanding of immune- and tumour-cell biology has led to an explosion of research into potential ways to harness the immune system to kill cancer. By Emily Elert.

    • Emily Elert

  • Letter |

    Interferon-inducible transmembrane (IFITM) protein 3 is shown to be an innate defence mechanism against viral infection in vivo; furthermore, a subset of the patients hospitalized during the H1N1 2009 pandemic carried a variant form of the IFITM3 gene.

    • Aaron R. Everitt
    • , Simon Clare
    •  & Paul Kellam

  • Article |

    A genome-wide analysis determines the contribution of DNA breaks and nuclear interactions to the formation of random versus recurrent translocations; whereas random translocations follow nuclear interaction profiles, the frequency of recurrent translocations is directly proportional to the amount of DNA damage at translocation partners.

    • Ofir Hakim
    • , Wolfgang Resch
    •  & Rafael Casellas

  • Review Article |

    An overview of the latest advances in cancer immunotherapy.

    • Ira Mellman
    • , George Coukos
    •  & Glenn Dranoff

  • News & Views |

    The structure of an antibody that potently neutralizes a wide range of HIV-1 strains, together with a minimal antigen mimic, is an advance towards the design of vaccines that may elicit protective responses. See Article p.336

    • Quentin J. Sattentau

  • News & Views |

    Magnesium binds to enzymes and nucleic acids and is essential for their activity. It emerges that this ion can also function as a signalling molecule with a crucial role in the immune system. See Article p.471

    • Ning Wu
    •  & André Veillette

  • News & Views |

    The TH17 helper cells of the immune system have a dark side: they mediate autoimmune disorders. Two drugs that prevent the differentiation and activity of these cells might be of therapeutic value. See Letters p.486 & p.491

    • Anton M. Jetten

  • News & Views |

    Spikes on the surface of HIV to which antibodies can bind are sparse. One of nature's solutions is to sometimes produce antibodies that bind tightly to a spike with one arm and grab another structure with the other arm. See Letter p.591

    • Andreas Plückthun

  • Letter |

    Human immunodeficiency virus (HIV) fails to induce interferon in the cells that it infects, but the underlying mechanisms are not known. These authors show that the virus can in fact activate the interferon pathway in dendritic cells when the usual block to infection is bypassed. Dendritic cell activation depends on the HIV-1 capsid/cyclophilin A interaction, which is known to have a role in HIV-1 infectivity.

    • Nicolas Manel
    • , Brandon Hogstad
    •  & Dan R. Littman

  • Letter |

    B cells are activated by many different antigens to produce appropriate antibodies. B cells express up to 120,000 B-cell antigen receptor (BCR) complexes on their surface, but how do these complexes remain silent on resting B cells, and how are they activated? It is found here that the BCR on resting cells forms oligomers, and that these may be an autoinhibited form of the receptor. Disruption of the oligomer shifts B cells towards activation.

    • Jianying Yang
    •  & Michael Reth

  • Outlook |

    HIV keeps the immune system in a hyperactive state, gradually leading to its ruin, reports Emma Marris.

    • Emma Marris

  • Outlook |

    Sarah DeWeerdt describes the intricate relationship between HIV and the host immune system, each influencing the other's next moves.

    • Sarah DeWeerdt

  • News & Views |

    Toll receptors trigger immune responses through adaptor proteins and kinase enzymes. Structural studies reveal that hierarchical assembly of these proteins into a helical tower initiates downstream signalling events.

    • Steven A. Wasserman

  • Letter |

    Here, a new type of innate effector leukocyte cell — the nuocyte — is described and characterized. It is shown that interleukin (IL)25 and IL33 drive the expansion of the nuocyte population, that these cells secrete IL13, and that they are required for protection against helminth infection.

    • Daniel R. Neill
    • , See Heng Wong
    •  & Andrew N. J. McKenzie

  • Letter |

    In multicellular organisms, apoptotic cells are removed from tissues by phagocytes, which recognize and engulf the dying cells. The molecular mechanisms underlying the subsequent degradation of the cells have been unclear. Here, two evolutionarily conserved genes have been identified that are required for such processing in Caenorhabditis elegans and mammals. An understanding of these events could lead to new treatments for diseases associated with poor engulfment and destruction of dying cells.

    • Jason M. Kinchen
    •  & Kodi S. Ravichandran

  • News |

    Immune cells seem to spark recurrent prostate cancer in mice.

    • Brian Vastag

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