Hormone receptors articles within Nature

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  • Article |

    β2-adrenergic receptor(β2AR) signalling induces ERK activity at endosomes, but not at the plasma membrane, and this activity is dependent on active, endosome-localized Gαs and requires ligand-stimulated β2AR endocytosis.

    • Yonghoon Kwon
    • , Sohum Mehta
    •  & Jin Zhang

  • Article |

    X-ray crystallography and cryo-electron microscopy structures of the transcriptional repressor of the methylomycin gene cluster, MmfR, reveal the molecular basis for regulation of antibiotic biosynthesis by AHFCA hormones in Actinobacteria.

    • Shanshan Zhou
    • , Hussain Bhukya
    •  & Christophe Corre

  • Article |

    High levels of the sexually dimorphic hormone ecdysone, produced by active ovaries in Drosophila, promote the proliferation of stem cells in the female gut and maximize reproductive fitness, but also increase female susceptibility to age-dependent dysplasia and tumorigenesis.

    • Sara Mahmoud H. Ahmed
    • , Julieta A. Maldera
    •  & Bruce A. Edgar

  • Letter |

    Some types of anaemia do not respond to erythropoietin (Epo) treatment because patients do not have sufficient numbers of Epo-sensitive erythroid precursor cells; here, two agonists of PPAR-α are found to synergize with glucocorticoid treatment to promote early erythroid progenitor self-renewal, increasing the production of mature red blood cells in both human and mouse cultures and alleviating anaemia in mouse models.

    • Hsiang-Ying Lee
    • , Xiaofei Gao
    •  & Harvey F. Lodish

  • Letter |

    Conformation-specific antibodies capable of monitoring the activation state of a G-protein-coupled seven-transmembrane receptor, the β2-adrenoceptor, reveals receptor and G-protein activation not only in the plasma membrane, but also in the endosome.

    • Roshanak Irannejad
    • , Jin C. Tomshine
    •  & Mark von Zastrow

  • Article |

    The F-box protein CORONATINE INSENSITIVE 1 (COI1) mediates jasmonate signalling by promoting hormone-dependent ubiquitylation and degradation of the JASMONATE ZIM DOMAIN (JAZ) family of transcriptional repressors. These authors elucidate the mechanism of jasmonate perception. They present structural and pharmacological data to show that the true jasmonate receptor is a complex of both COI1 and JAZ. In addition, inositol pentakisphosphate functions as a critical component of the hormone receptor complex.

    • Laura B. Sheard
    • , Xu Tan
    •  & Ning Zheng

  • Letter |

    The amino-terminal tails of histone proteins are subject to a variety of post-translational modifications; addition or removal of these 'marks' facilitates gene activation or silencing. Here, a mechanism is defined that modulates the activity of the dual-specificity histone demethylase LSD1 during androgen-dependent transcription. Androgen-dependent signalling through protein kinase C beta I leads to phosphorylation of a histone amino acid, which prevents demethylation of an adjacent amino acid by LSD1.

    • Eric Metzger
    • , Axel Imhof
    •  & Roland Schüle

  • Letter |

    Peptide hormones such as oxytocin and vasopressin influence social behaviour in several mammalian species. Here it is shown that a population of interneurons in the rat olfactory bulb releases vasopressin, and that vasopressin signalling is required in the olfactory system for proper social recognition in rats. Although vasopressin may not work in exactly the same way in humans, social recognition mediated by experience-dependent vasopressin release may be common.

    • Vicky A. Tobin
    • , Hirofumi Hashimoto
    •  & Mike Ludwig

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