Cell signalling articles within Nature

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  • Article
    | Open Access

    Signalling by the developmental morphogen BMP2 through the transcription factor SMAD1 has a key role in controlling the glutamatergic innervation of parvalbumin-expressing interneurons and maintaining the balance between excitation and inhibition in the mammalian cortex.

    • Zeynep Okur
    • , Nadia Schlauri
    •  & Peter Scheiffele

  • Article |

    The molecular basis of OSCA/TMEM63 channel mechanosensitivity was investigated by determining 44 cryogenic electron microscopy structures of channels in different environments, expanding understanding of channel-mediated mechanotransduction and pore formation, with implications for two protein families.

    • Yaoyao Han
    • , Zijing Zhou
    •  & Yixiao Zhang

  • Article |

    Time-resolved cryo-EM is used to capture structural transitions during G-protein activation stimulated by a G-protein-coupled receptor.

    • Makaía M. Papasergi-Scott
    • , Guillermo Pérez-Hernández
    •  & Georgios Skiniotis

  • Article
    | Open Access

    The demethylase KDM5C, mutations in which often lead to intellectual disability, is identified as a crucial player in regulating the precise timing of neurodevelopment together with the WNT signalling pathway.

    • Violetta Karwacki-Neisius
    • , Ahram Jang
    •  & Yang Shi

  • Article
    | Open Access

    In zebrafish embryos, active complexes of Wnt5b and its membrane-bound receptor Ror2 are transported between cells via cellular protrusions called cytonemes to initiate paracrine Wnt5b signalling in cells that do not endogenously express the receptor.

    • Chengting Zhang
    • , Lucy Brunt
    •  & Steffen Scholpp

  • Article
    | Open Access

    Several independent lines of evidence demonstrated long-term potentiation induction by a structural function of calmodulin-dependent protein kinase II rather than by its enzymatic activity.

    • Jonathan E. Tullis
    • , Matthew E. Larsen
    •  & K. Ulrich Bayer

  • Article |

    Structural studies on the complex containing G-protein-coupled receptor kinase 2 (GRK2), neurotensin receptor 1 (NTSR1), Gαq and the arrestin-biased ligand SBI-553 provide insights into these interactions and a foundation for the design of arrestin-biased ligands for G-protein-coupled receptors.

    • Jia Duan
    • , Heng Liu
    •  & H. Eric Xu

  • Article |

    In mice, sympathetic nerves associated with female mammary glands control the secretion of thermogenesis-controlling factors by epithelial cells in the adipocyte niche, revealing sex-specific differences in adipose thermogenesis.

    • Sanil Patel
    • , Njeri Z. R. Sparman
    •  & Prashant Rajbhandari

  • Article
    | Open Access

    We uncover the mechanism underlying the restriction point phenomenon, suggest a role for cyclin-dependent kinase 4 and 6 activity in S and G2 phases, and explain the behaviour of cells following loss of mitogen signalling.

    • James A. Cornwell
    • , Adrijana Crncec
    •  & Steven D. Cappell

  • Article
    | Open Access

    We identify a highly controlled cytosolic surveillance mechanism that integrates independent mitochondrial stress signals to initiate the mitochondrial unfolded protein response (UPR), revealing a link between mitochondrial and cytosolic proteostasis.

    • F. X. Reymond Sutandy
    • , Ines Gößner
    •  & Christian Münch

  • Article
    | Open Access

    A non-covalent inhibitor that binds preferentially to the inactive state of KRAS while sparing NRAS and HRAS is reported, indicating that most KRAS oncoproteins cycle between an active state and an inactive state in cancer cells.

    • Dongsung Kim
    • , Lorenz Herdeis
    •  & Piro Lito

  • Article |

    A new specific, small-molecule activator of the PI3Kα isoform (UCL-TRO-1938) identified through high-throughput screening can transiently activate PI3K signalling and biological responses in cells and tissues, with potential therapeutic applications in tissue protection and regeneration.

    • Grace Q. Gong
    • , Benoit Bilanges
    •  & Bart Vanhaesebroeck

  • Article |

    Gene expression analysis in muscle tissues showed upregulation of ectodysplasin A2 receptor in tumour-bearing mice and patients with cachectic cancer, and thus therapeutic targeting of relevant pathways may be beneficial in prevention of muscle loss.

    • Sevval Nur Bilgic
    • , Aylin Domaniku
    •  & Serkan Kir

  • Article
    | Open Access

    Biochemical and molecular dynamics studies show that the third intracellular loop of G protein-coupled receptors autoregulates the receptor activity and tunes the signalling specificity by controlling access to the G protein-binding site.

    • Fredrik Sadler
    • , Ning Ma
    •  & Sivaraj Sivaramakrishnan

  • Article |

    Logic gating is used to develop a CAR T cell platform that is highly specific and allows the activity of T cells to be restricted to the encounter of two antigens, thus reducing on-target, off-tumour toxicity.

    • Aidan M. Tousley
    • , Maria Caterina Rotiroti
    •  & Robbie G. Majzner

  • Article |

    A technique to detect the release of N-terminal fragments of Drosophila adhesion G-protein-coupled receptors (aGPCRs) provides insight into the dissociation of aGPCRs, and shows that receptor autoproteolysis enables non-cell-autonomous activity of aGPCRs in the brain.

    • Nicole Scholz
    • , Anne-Kristin Dahse
    •  & Tobias Langenhan

  • Article
    | Open Access

    Cryogenic-electron microscopy is used to determine the structure of TFEB as presented to mTORC1 for phosphorylation and an explanation is found for the strong dependence of TFEB phosphorylation on FLCN and the RagC GDP state.

    • Zhicheng Cui
    • , Gennaro Napolitano
    •  & James H. Hurley

  • Article
    | Open Access

    Aberrant crosstalk between cancer stem cells and their microenvironment triggers angiogenesis and TGFβ signalling, creating conditions that are conducive for hijacking leptin and leptin receptor signalling, which in turn launches downstream PI3K–AKT–mTOR signalling during the benign-to-malignant transition.

    • Shaopeng Yuan
    • , Katherine S. Stewart
    •  & Elaine Fuchs

  • Article |

    β2-adrenergic receptor(β2AR) signalling induces ERK activity at endosomes, but not at the plasma membrane, and this activity is dependent on active, endosome-localized Gαs and requires ligand-stimulated β2AR endocytosis.

    • Yonghoon Kwon
    • , Sohum Mehta
    •  & Jin Zhang

  • Article
    | Open Access

    The cryo-EM structure of the yeast SEA complex suggests that SEACAT functions as a scaffold for binding TORC1 regulators.

    • Lucas Tafur
    • , Kerstin Hinterndorfer
    •  & Robbie Loewith

  • Article |

    Detailed mechanistic insight into fetal globin gene induction during hypoxia-associated stress erythropoiesis provides new therapeutic approaches to treat β-haemoglobinopathies, such as sickle cell disease and β-thalassaemia.

    • Ruopeng Feng
    • , Thiyagaraj Mayuranathan
    •  & Mitchell J. Weiss

  • Article
    | Open Access

    Cleaved and intact type I collagen have different effects on pancreatic ductal adenocarcinoma (PDAC), and remodelling of type I collagen—mediated through DDR1 signalling—is a prognostic indicator for the survival of patients with PDAC.

    • Hua Su
    • , Fei Yang
    •  & Michael Karin

  • Article |

    The 3D structure of the human nutrient-sensing complex GATOR2 is resolved using cryo-electron microscopy.

    • Max L. Valenstein
    • , Kacper B. Rogala
    •  & David M. Sabatini

  • Article
    | Open Access

    Untargeted metabolomics demonstrate that apoptotic brown adipocytes release a specific pattern of metabolites with purine metabolites being highly enriched, and inosine is identified as a metabolite released during apoptosis regulating thermogenic fat and counteracting obesity.

    • Birte Niemann
    • , Saskia Haufs-Brusberg
    •  & Alexander Pfeifer

  • Article |

    tDeclining YAP/TAZ mechanotransduction drives ageing by unleashing cGAS–STING signalling, a pillar of innate immunity, so sustaining YAP/TAZ mechanosignalling or inhibiting STING present promising approaches for limiting senescence-associated inflammation and improving healthy ageing.

    • Hanna Lucie Sladitschek-Martens
    • , Alberto Guarnieri
    •  & Stefano Piccolo

  • Article
    | Open Access

    The molecular target of the antidiabetic medicine metformin is identified as PEN2, a subunit of γ-secretases, and the PEN2–ATP6AP1 axis offers potential targets for screening for metformin substitutes.

    • Teng Ma
    • , Xiao Tian
    •  & Sheng-Cai Lin

  • Article |

    Cryo-electron microscopy studies show that dynamic coordination of Na+ in the ion channel of Dispatched homologue 1 and the transmembrane Na+ gradient have key roles in exporting lipid-modified Hedgehog protein signal.

    • Qianqian Wang
    • , Daniel E. Asarnow
    •  & Philip A. Beachy

  • Article
    | Open Access

    Auxin induces transmembrane-kinase-dependent activation of H+-ATPase in the plasma membrane through phosphorylation of its penultimate threonine residue, promoting apoplastic acidification and hypocotyl cell elongation in Arabidopsis.

    • Wenwei Lin
    • , Xiang Zhou
    •  & Zhenbiao Yang

  • Article
    | Open Access

    Cryo-EM structure of Nf1 protein is reported, revealing closed and open conformations that regulate interaction with Ras oncogene, setting the stage for understanding the mechanistic action of Nf1 and how disease mutations lead to dysfunction.

    • Andreas Naschberger
    • , Rozbeh Baradaran
    •  & Marta Carroni

  • Article |

    SAR1B, which is conserved between mammals and nematodes, is a leucine sensor that is involved in regulating mTORC1 signalling and potentially has a role in the development of lung cancer.

    • Jie Chen
    • , Yuhui Ou
    •  & Ying Liu

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