Featured
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Dispatched uses Na+ flux to power release of lipid-modified Hedgehog
Cryo-electron microscopy studies show that dynamic coordination of Na+ in the ion channel of Dispatched homologue 1 and the transmembrane Na+ gradient have key roles in exporting lipid-modified Hedgehog protein signal.
- Qianqian Wang
- , Daniel E. Asarnow
- & Philip A. Beachy
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Glypicans shield the Wnt lipid moiety to enable signalling at a distance
Genetic studies in Drosophila combined with structural analyses show that glypicans bind palmitoylate moieties in Wnt ligands, and thus shield Wnt ligands from their aqueous environments to enable them to signal to their distant receptors.
- Ian J. McGough
- , Luca Vecchia
- & Jean-Paul Vincent
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Letter |
Smoothened stimulation by membrane sterols drives Hedgehog pathway activity
The crystal structure of active mouse SMO in complex with the SAG21k agonist and a stabilizing intracellular binding nanobody reveals the structural basis of SMO regulation by PTCH1.
- Ishan Deshpande
- , Jiahao Liang
- & Aashish Manglik
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Article |
Frizzled proteins are colonic epithelial receptors for C. difficile toxin B
Here, a genome-wide CRISPR–Cas9 screen is used to identify the Wnt receptors frizzled as physiologically relevant Clostridium difficile toxin B receptors, providing new therapeutic targets for treating C. difficile infections.
- Liang Tao
- , Jie Zhang
- & Min Dong
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Article |
Dpp spreading is required for medial but not for lateral wing disc growth
The morphogen Decapentaplegic (Dpp) has been implicated in both wing patterning and growth in fruitflies; here, a nanobody-based morphotrap approach has been developed that rules out a role for the Dpp gradient in regulating lateral wing growth.
- Stefan Harmansa
- , Fisun Hamaratoglu
- & Emmanuel Caussinus
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Article |
Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver
In the uninjured liver, a population of self-renewing, diploid hepatocytes is identified near the central vein; these cells respond to Wnt signals that are provided by the adjacent central vein endothelial cells, and can give rise to all other hepatocytes to maintain liver homeostasis.
- Bruce Wang
- , Ludan Zhao
- & Roel Nusse
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Article |
Patterning and growth control by membrane-tethered Wingless
Replacement of the wingless (wg) gene in Drosophila with one that expresses a membrane-tethered form of Wg results in viable flies with normally patterned appendages of nearly the right size; early wg transcription and memory of signalling ensure continued target-gene expression in the absence of Wg release, even though the spread of Wg could boost cell proliferation.
- Cyrille Alexandre
- , Alberto Baena-Lopez
- & Jean-Paul Vincent