Lipid signalling articles within Nature

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• Letter | 05 June 2019

  Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric G_i

  Cryo-electron microscopy structure of the human Smoothened protein bound to 24(S),25-epoxycholesterol and a heterotrimeric G_i protein provides insights into the activation of a Frizzled-class G-protein-coupled receptor and Hedgehog signal transduction.

  • Xiaofeng Qi
  • , Heng Liu
  •  & Xiaochun Li

• Letter | 24 April 2019

  SR-B1 drives endothelial cell LDL transcytosis via DOCK4 to promote atherosclerosis

  The SR-B1 receptor partners with DOCK4 and RAC1 to drive the uptake and transcytosis of LDL in endothelial cells, thereby promoting atherosclerosis in mice.

  • Linzhang Huang
  • , Ken L. Chambliss
  •  & Philip W. Shaul

• Letter | 09 August 2017

  Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA₆

  Determination of the crystal structure of the zebrafish LPA₆ receptor shows that the lipid ligand binds to an unusual ligand-binding pocket in the receptor that is laterally accessible through the membrane.

  • Reiya Taniguchi
  • , Asuka Inoue
  •  & Osamu Nureki

• News & Views | 22 June 2011

  A lipid for fat disorders

  A high-fat diet often leads to metabolic disorders such as diabetes, fatty liver disease and obesity. One lipid, however, might mitigate these effects through an unexpected signalling role in the nucleus. See Letter p.506

  • Holly A. Ingraham