Insulin signalling articles within Nature

Featured

• Article | 27 January 2021

  Inceptor counteracts insulin signalling in β-cells to control glycaemia

  The insulin inhibitory receptor (inceptor) is identified as a negative regulator of insulin and IGF1 signalling that could be targeted for β-cell regeneration in treatments for diabetes.

  • Ansarullah
  • , Chirag Jain
  •  & Heiko Lickert

• Letter | 05 May 2013

  The microRNA miR-235 couples blast-cell quiescence to the nutritional state

  A microRNA, miR-235, is identified that acts downstream of the insulin/insulin growth factor signalling pathway to modulate the quiescence of blast cells in Caenorhabditis elegans.

  • Hidefumi Kasuga
  • , Masamitsu Fukuyama
  •  & Toshiaki Katada

• Research Highlights | 22 June 2011

  Cellular cues to compulsive eating

• Letter | 08 June 2011

  MicroRNAs 103 and 107 regulate insulin sensitivity

  • Mirko Trajkovski
  • , Jean Hausser
  •  & Markus Stoffel

• Research Highlights | 01 September 2010

  Zoology: Insulin drops, so does sex

• Letter | 07 July 2010

  A new DAF-16 isoform regulates longevity

  The insulin/IGF-1 signalling (IIS) pathway is involved in various biological processes, including regulation of longevity. In the worm Caenorhabditis elegans, the transcription factor DAF-16a, one of two isoforms, has a major role in this pathway, regulating longevity, stress response and dauer diapause. These authors describe a new isoform, DAF-16d/f, which is also important in the regulation of lifespan. The DAF-16 isoforms functionally cooperate to fine-tune IIS-mediated processes in the context of a whole organism.

  • Eun-Soo Kwon
  • , Sri Devi Narasimhan
  •  & Heidi A. Tissenbaum