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Dopaminergic systems create reward seeking despite adverse consequences
In Drosophila, a subpopulation of reward-encoding dopaminergic neurons antagonizes punishment-encoding neurons and can override punishment or hunger cues in favour of reward-seeking behaviour.
- Kristijan D. Jovanoski
- , Lucille Duquenoy
- & Scott Waddell
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Dopaminergic error signals retune to social feedback during courtship
In male zebra finches, dopamine responses in Area X are retuned away from self-evaluation of song performance and towards social feedback to song performance when females are present.
- Andrea Roeser
- , Vikram Gadagkar
- & Jesse H. Goldberg
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Article
| Open Access
No evidence for magnetic field effects on the behaviour of Drosophila
Following testing of magnetic field effects on 97,658 flies moving in a two-arm maze and on 10,960 flies performing spontaneous escape behaviour (negative geotaxis), no evidence was found for magnetically sensitive behaviour in Drosophila.
- Marco Bassetto
- , Thomas Reichl
- & Henrik Mouritsen
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Article |
A microbiome-dependent gut–brain pathway regulates motivation for exercise
It is demonstrated that the brain circuitry involved in regulating the motivation for physical activity is not strictly central nervous system autonomous but is shaped by peripheral influences that originate in the intestinal microbial community.
- Lenka Dohnalová
- , Patrick Lundgren
- & Christoph A. Thaiss
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Article |
An endogenous opioid circuit determines state-dependent reward consumption
Studies in mice show that µ-opioid peptide receptor regulation of reward consumption in mice acts through a specific dorsal raphe to nucleus accumbens projection and requires enkephalin-producing neurons.
- Daniel C. Castro
- , Corinna S. Oswell
- & Michael R. Bruchas
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Article |
Hypothalamic dopamine neurons motivate mating through persistent cAMP signalling
A population of hypothalamic dopamine neurons sustains mating drive in male mice through a persistent mode of biochemical signalling in target neurons.
- Stephen X. Zhang
- , Andrew Lutas
- & Mark L. Andermann
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Article |
Sexual arousal gates visual processing during Drosophila courtship
Specific neurons in the fly brain that are activated when males are aroused modulate visual processing to underlie courtship.
- Tom Hindmarsh Sten
- , Rufei Li
- & Vanessa Ruta
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Article |
Cell-type-specific asynchronous modulation of PKA by dopamine in learning
The net PKA activities in each class of spiny projection neuron in the nucleus accumbens of the mouse are dichotomously modulated by asynchronous positive and negative dopamine signals during different phases of learning.
- Suk Joon Lee
- , Bart Lodder
- & Bernardo L. Sabatini
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Article |
Internal state dynamics shape brainwide activity and foraging behaviour
During foraging for live prey, zebrafish larvae alternate between persistent exploitation and exploration behavioural states that correlate with distinct patterns of neuronal activation.
- João C. Marques
- , Meng Li
- & Jennifer M. Li
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Article |
Dissociable dopamine dynamics for learning and motivation
The dopamine projection from midbrain dopamine cells to the nucleus accumbens is essential for normal motivation, yet motivation-related changes in nucleus accumbens dopamine release occur independently of dopamine cell firing.
- Ali Mohebi
- , Jeffrey R. Pettibone
- & Joshua D. Berke
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Letter |
Dopamine enhances signal-to-noise ratio in cortical-brainstem encoding of aversive stimuli
Dopamine in the medial prefrontal cortex modulates behavioural responses to aversive stimuli by increasing the signal-to-noise ratio of neurons projecting to the dorsal periaqueductal grey.
- Caitlin M. Vander Weele
- , Cody A. Siciliano
- & Kay M. Tye
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Letter |
The coding of valence and identity in the mammalian taste system
The identity and hedonic value of tastes are encoded in distinct neural substrates; in mice, the amygdala is necessary and sufficient to drive valence-specific behaviours in response to bitter or sweet taste stimuli, and the cortex can independently represent taste identity.
- Li Wang
- , Sarah Gillis-Smith
- & Charles S. Zuker
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Hierarchical neural architecture underlying thirst regulation
Thirst is regulated by hierarchical neural circuits in the lamina terminalis, and these integrate the instinctive need for water with consequent drinking behaviour to maintain internal water homeostasis.
- Vineet Augustine
- , Sertan Kutal Gokce
- & Yuki Oka
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Perspective |
Importance of investing in adolescence from a developmental science perspective
Insights into windows of opportunity that will have strong positive impacts on the trajectories of health, education, social and economic success of adolescents are reviewed.
- Ronald E. Dahl
- , Nicholas B. Allen
- & Ahna Ballonoff Suleiman
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Article |
Homeostatic circuits selectively gate food cue responses in insular cortex
A combination of microprism-based cellular imaging to monitor insular cortex visual cue responses in behaving mice across hunger states with circuit mapping and manipulations reveals a neural basis for state-specific biased processing of motivationally relevant cues.
- Yoav Livneh
- , Rohan N. Ramesh
- & Mark L. Andermann
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Letter |
Dynamic corticostriatal activity biases social bonding in monogamous female prairie voles
In a prairie vole (Microtus ochrogaster) model of social bonding, a functional circuit from the prefrontal cortex to nucleus accumbens is dynamically modulated to enhance females’ affiliative behaviour towards a partner.
- Elizabeth A. Amadei
- , Zachary V. Johnson
- & Robert C. Liu
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Article |
Autism gene Ube3a and seizures impair sociability by repressing VTA Cbln1
Increasing expression of the autism-associated gene Ube3a, either alone or in combination with seizures, not only impairs sociability in mice but also reduces expression of the synaptic organizer Cbln1 in the ventral tegmental area, thus weakening glutamatergic transmission.
- Vaishnav Krishnan
- , David C. Stoppel
- & Matthew P. Anderson
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Letter |
Prefrontal cortex output circuits guide reward seeking through divergent cue encoding
Neurons that project from the prefrontal cortex to either the nucleus accumbens or paraventricular thalamus receive different inputs, differentially encode reward-predictive cues, and have opposing effects on reward seeking during cue presentation.
- James M. Otis
- , Vijay M. K. Namboodiri
- & Garret D. Stuber
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Review Article |
The effects of Δ9-tetrahydrocannabinol on the dopamine system
A review into the complex effects of Δ9-tetrahydrocannabinol on the dopamine system, examining data from animal and human studies and discussing the necessary future direction of research.
- Michael A. P. Bloomfield
- , Abhishekh H. Ashok
- & Oliver D. Howes
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Article |
Rapid signalling in distinct dopaminergic axons during locomotion and reward
Fast phasic signals in dopaminergic axons in the dorsal striatum occur during, and can induce, motor accelerations in mice, and these signals are transmitted by a largely distinct population of dopaminergic axons from those that signal reward.
- M. W. Howe
- & D. A. Dombeck
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Letter |
Basal forebrain projections to the lateral habenula modulate aggression reward
Here, the circuits underlying the motivational or rewarding component to aggression are deconstructed, showing that an inhibitory projection from the basal forebrain to the lateral habenula bi-directionally controls this aspect of aggression.
- Sam A. Golden
- , Mitra Heshmati
- & Scott J. Russo
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Letter |
Opponent and bidirectional control of movement velocity in the basal ganglia
Activity in the direct and indirect basal ganglia pathways can bidirectionally control the speed of movements that underlie reward-seeking actions in mice without affecting motivation.
- Eric A. Yttri
- & Joshua T. Dudman
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Letter |
Nucleus accumbens D2R cells signal prior outcomes and control risky decision-making
Increased activity of dopamine receptor type-2 (D2R)-expressing cells in the nucleus accumbens of rats during a ‘decision’ period reflects a ‘loss’ outcome of the previous decision and predicts a subsequent safe choice; by artificially increasing the activity of D2R neurons during the decision period, risk-seeking rats could be converted to risk-avoiding rats.
- Kelly A. Zalocusky
- , Charu Ramakrishnan
- & Karl Deisseroth
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Letter |
A thalamic input to the nucleus accumbens mediates opiate dependence
The paraventricular nucleus of the thalamus to the nucleus accumbens pathway mediates physical signs and aversive memory of opiate withdrawal.
- Yingjie Zhu
- , Carl F. R. Wienecke
- & Xiaoke Chen
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Letter |
Arithmetic and local circuitry underlying dopamine prediction errors
Dopamine neurons in the ventral tegmental area calculate reward prediction error by subtracting input from neighbouring GABA neurons.
- Neir Eshel
- , Michael Bukwich
- & Naoshige Uchida
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Letter |
A circuit mechanism for differentiating positive and negative associations
Neurons in the basolateral amygdala projecting to canonical fear or reward circuits undergo opposing changes in synaptic strength following fear or reward conditioning, and selectively activating these projection-target-defined neural populations causes either negative or positive reinforcement, respectively.
- Praneeth Namburi
- , Anna Beyeler
- & Kay M. Tye
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Letter |
Thirst driving and suppressing signals encoded by distinct neural populations in the brain
Two genetically distinct populations of neurons in the subfornical organ of mice can either induce thirst and water-seeking behaviour or suppress thirst, regardless of the hydration status of the animal.
- Yuki Oka
- , Mingyu Ye
- & Charles S. Zuker
Neural landscape diffusion resolves conflicts between needs across time