Nuclear pore complex articles within Nature

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  • Article |

    We report the cryo-electron microscopy structure of native pre-60S particles trapped in the channel of the yeast nuclear pore complex, suggesting a translocation model for the export of pre-60S particles through the complex.

    • Zongqiang Li
    • , Shuaijiabin Chen
    •  & Sen-Fang Sui

  • Article
    | Open Access

    Single-molecule calibrated live microscopy and computational modelling have revealed that human nuclear pore complex assembly takes different pathways during the exit from mitosis and during nuclear growth in interphase.

    • Shotaro Otsuka
    • , Jeremy O. B. Tempkin
    •  & Jan Ellenberg

  • Article |

    In-cell structural studies in Saccharomyces cerevisiae reveal that the configuration of the Nup159 complex is a key determinant of the mRNA export function of the nuclear pore complex, and suggest a model in which nuclear pore complexes are degraded via the autophagy machinery.

    • Matteo Allegretti
    • , Christian E. Zimmerli
    •  & Martin Beck

  • Article |

    The structure of the yeast nuclear pore complex, determined at sub-nanometre precision using an integrative approach that combines a wide range of data, reveals details of its architecture, transport mechanism and evolutionary origins.

    • Seung Joong Kim
    • , Javier Fernandez-Martinez
    •  & Michael P. Rout

  • Letter |

    The most comprehensive architectural model to date of the nuclear pore complex reveals previously unknown local interactions, and a role for nucleoporin 358 in Y-complex oligomerization.

    • Alexander von Appen
    • , Jan Kosinski
    •  & Martin Beck

  • Letter |

    Nuclear pore complexes selectively transport cargos across the nuclear envelope. Here, a nuclear transport assay has been developed that allows the movement of single cargo proteins to be followed in real time. A succession of transport substeps is observed, and the NPC is found to be functionally asymmetric to importing cargos. The study provides insight into the mechanism of selective transport through the NPC.

    • Alan R. Lowe
    • , Jake J. Siegel
    •  & Jan T. Liphardt

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