Organocatalysis articles within Nature

Featured

• Article
  01 March 2023 | Open Access

  Catalytic asymmetric synthesis of cannabinoids and menthol from neral

  An unsymmetric, strong and confined chiral acid, a highly fluorinated imino-imidodiphosphate, catalyses the selective conversion of neral to (1R,6S)-trans-isopiperitenol, enabling sustainable routes to menthol and cannabinoids.

  • Joyce A. A. Grimm
  • , Hui Zhou
  •  & Benjamin List

• Article | 16 June 2022

  Site-selective, stereocontrolled glycosylation of minimally protected sugars

  A simplified synthesis strategy for stereo- and site-selective glycosylations, using minimally protected mono- and disaccharides and thiourea small-molecule catalysts, enables highly selective functionalization of carbohydrates.

  • Qiuhan Li
  • , Samuel M. Levi
  •  & Eric N. Jacobsen

• Article | 14 February 2022

  Synthesis of chiral sulfinate esters by asymmetric condensation

  A synthetic strategy for the stereoselective preparation of sulfinate esters and related sulfur stereogenic centres via asymmetric condensation expands the drug discovery toolbox for these compounds.

  • Xin Zhang
  • , Esther Cai Xia Ang
  •  & Choon-Hong Tan

• Article | 25 April 2018

  Quaternary stereocentres via an enantioconvergent catalytic S_N1 reaction

  Cooperation between a chiral hydrogen-bond-donor catalyst and a strong Lewis-acid promoter in an S_N1-type reaction mediates the formation of tertiary carbocations and enables control over enantioselectivity and product distribution.

  • Alison E. Wendlandt
  • , Prithvi Vangal
  •  & Eric N. Jacobsen

• Review Article | 01 February 2018

  Enhancing the potential of enantioselective organocatalysis with light

  This Review discusses recent developments in the combination of organocatalysis and photochemistry for the activation of molecules, which has enabled previously inaccessible reaction pathways and influenced many fields of chemical research.

  • Mattia Silvi
  •  & Paolo Melchiorre

• Letter | 13 April 2016

  Asymmetric catalytic formation of quaternary carbons by iminium ion trapping of radicals

  A combination of photoredox and asymmetric organic catalysis enables enantioselective radical conjugate additions to β,β-disubstituted cyclic enones to construct quaternary carbon stereocentres with high fidelity.

  • John J. Murphy
  • , David Bastida
  •  & Paolo Melchiorre

• Letter | 04 March 2015

  The direct arylation of allylic sp³ C–H bonds via organic and photoredox catalysis

  Photoredox and organic catalysis are combined to achieve broadly effective direct arylation of allylic carbon–hydrogen bonds under mild conditions; this carbon–carbon bond forming reaction readily accommodates a wide range of alkene and electron-deficient arene coupling partners.

  • James D. Cuthbertson
  •  & David W. C. MacMillan

• News | 15 August 2012

  Amino acid provides shortcut to drugs

  Organocatalyst halves synthesis of prostaglandin family.

  • Katharine Sanderson

• Letter | 15 August 2012

  Stereocontrolled organocatalytic synthesis of prostaglandin PGF_2α in seven steps

  A concise new synthesis of the most complex of the prostaglandins—diverse hormone-like chemical messengers—should make existing prostaglandin-based drugs cheaper and also facilitate other related syntheses.

  • Graeme Coulthard
  • , William Erb
  •  & Varinder K. Aggarwal

• Article | 13 July 2011

  Collective synthesis of natural products by means of organocascade catalysis

  • Spencer B. Jones
  • , Bryon Simmons
  •  & David W. C. MacMillan