Osteoarthritis articles within Nature

Featured

• Article
  03 January 2024 | Open Access

  Na_v1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis

  The voltage-gated sodium channel Na_v1.7 has a dual role in osteoarthritis—in chondrocytes, it promotes joint damage, and in dorsal root ganglia neurons, it increases pain transmission.

  • Wenyu Fu
  • , Dmytro Vasylyev
  •  & Chuan-ju Liu

• Letter | 06 February 2019

  The CH25H–CYP7B1–RORα axis of cholesterol metabolism regulates osteoarthritis

  In experimentally induced osteoarthritis, chondrocytes show increased uptake and metabolism of cholesterol, implicating the CH25H–CYP7B1–RORα axis in the pathogenesis of osteoarthritis.

  • Wan-Su Choi
  • , Gyuseok Lee
  •  & Jang-Soo Chun