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Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes
Single-cell transcriptomic and proteomic data from synovial tissue from individuals with rheumatoid arthritis classify patients into groups based on abundance of cell states that can provide insights into pathology and predict individual treatment responses.
- Fan Zhang
- , Anna Helena Jonsson
- & Soumya Raychaudhuri
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Article |
Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides
A study shows that cross-reactivity of microbial antigens and self-antigens presented by HLA-B*27 may be important in the pathogenesis of diseases associated with HLA-B*27 and identifies the shared binding motif responsible.
- Xinbo Yang
- , Lee I. Garner
- & K. Christopher Garcia
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Article |
Notch signalling drives synovial fibroblast identity and arthritis pathology
NOTCH3 signalling is shown to be the underlying driver of the differentiation and expansion of a subset of synovial fibroblasts implicated in the pathogenesis of rheumatoid arthritis.
- Kevin Wei
- , Ilya Korsunsky
- & Michael B. Brenner
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Letter |
The CH25H–CYP7B1–RORα axis of cholesterol metabolism regulates osteoarthritis
In experimentally induced osteoarthritis, chondrocytes show increased uptake and metabolism of cholesterol, implicating the CH25H–CYP7B1–RORα axis in the pathogenesis of osteoarthritis.
- Wan-Su Choi
- , Gyuseok Lee
- & Jang-Soo Chun
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Article |
PU.1 controls fibroblast polarization and tissue fibrosis
The transcription factor PU.1 is an essential regulator of the pro-fibrotic gene expression program in fibroblasts; PU.1 expression is upregulated in various fibrotic diseases, whereas inactivation of PU.1 induces regression of fibrosis in a number of organs.
- Thomas Wohlfahrt
- , Simon Rauber
- & Andreas Ramming
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Letter |
Nonsense mutation in the LGR4 gene is associated with several human diseases and other traits
Analysis of whole-genome sequence data of Icelandic individuals has revealed a rare nonsense mutation within the LGR4 gene that is strongly associated with, among other things, low bone mineral density, late onset of menarche, and increased risk of biliary tract cancer.
- Unnur Styrkarsdottir
- , Gudmar Thorleifsson
- & Kari Stefansson
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Article |
Osteoprotection by semaphorin 3A
Semaphorin 3A (Sema3A) is shown to function as a protector of bone, by synchronously inhibiting osteoclastic bone resorption and promoting osteoblastic bone formation.
- Mikihito Hayashi
- , Tomoki Nakashima
- & Hiroshi Takayanagi
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News |
Wireless drug implant takes the trouble out of treatment
Microchip releases doses automatically, removing need for injections.
- Duncan Graham-Rowe
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News |
Antibodies linked to long-term Lyme symptoms
Researchers find molecules that might mark elusive syndrome.
- Amy Maxmen
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News |
Muscular dystrophy findings fuel French stem cell debate
Work shows the value of human embryonic stem cells for disease research.
- Alison Abbott
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News |
High hopes for arthritis drugs
Race is on to develop treatments that inhibit signalling proteins.
- Heidi Ledford
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News |
Scientists push for Lyme disease trials
Confusion over correct treatment for persistent symptoms clouds conference.
- Amy Maxmen
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News |
The skin disease that cures itself
Diseased cells have harnessed a cancer-causing mechanism to banish a mutant gene.
- Ewen Callaway
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News |
King Tut's death explained?
Experts question claims that malaria and osteonecrosis contributed to Pharaoh's decline.
- Declan Butler
Nav1.7 as a chondrocyte regulator and therapeutic target for osteoarthritis