Review Article |
Featured
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Article |
Synthon-based ligand discovery in virtual libraries of over 11 billion compounds
V-SYNTHES, a scalable and computationally cost-effective synthon-based approach to compound screening, identified compounds with a high affinity for CB2 and CB1 in a hierarchical structure-based screen of more than 11 billion compounds.
- Arman A. Sadybekov
- , Anastasiia V. Sadybekov
- & Vsevolod Katritch
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Article |
An open-source drug discovery platform enables ultra-large virtual screens
VirtualFlow, an open-source drug discovery platform, enables the efficient preparation and virtual screening of ultra-large ligand libraries to identify molecules that bind with high affinity to target proteins.
- Christoph Gorgulla
- , Andras Boeszoermenyi
- & Haribabu Arthanari
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Letter |
Discovery and characterization of small molecules that target the GTPase Ral
Using a structure-based approach, small molecule inhibitors that selectively target the GTPase Ral are identified and characterized; these first-generation inhibitors will be valuable tools for elucidating the Ral signalling pathway and constitute a step towards developing Ral-specific agents for cancer therapy.
- Chao Yan
- , Degang Liu
- & Dan Theodorescu
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Letter |
Genetics of rheumatoid arthritis contributes to biology and drug discovery
A genome-wide association study meta-analysis of more than 100,000 subjects of European and Asian ancestries reveals 42 new risk loci for rheumatoid arthritis, with follow-up studies identifying 98 biological candidate genes that are either already being targeted by drugs or could be in the future.
- Yukinori Okada
- , Di Wu
- & Robert M. Plenge