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Volume 28 Issue 8, August 2023

RNAscope fluorescent in situ hybridization (FISH) on coronal sections through mouse nucleus accumbens to quantify mRNA in specific cell types.  Expression of the interneuron marker Pvalb is shown in green and nuclei are labeled with DAPI in blue. Left, mRNA for the cell adhesion protein Cntnap4 is in white and the spiny projection neuron marker Ppp1r1b encoding DARPP-32 is in red. Right, mRNA for the perineuronal net protein Acan is in red. For more information see the article by Gallegos et al. on pages 3414-3428.

Volume 28 Issue 8

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  • A recent “umbrella” review examined various biomarkers relating to the serotonin system, and concluded there was no consistent evidence implicating serotonin in the pathophysiology of depression. We present reasons for why this conclusion is overstated, including methodological weaknesses in the review process, selective reporting of data, over-simplification, and errors in the interpretation of neuropsychopharmacological findings. We use the examples of tryptophan depletion and serotonergic molecular imaging, the two research areas most relevant to the investigation of serotonin, to illustrate this.

    • Sameer Jauhar
    • Danilo Arnone
    • Philip J. Cowen
    Comment Open Access
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