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The array of tools to image peroxisome regulation is still limited. Here, the authors develop improved fatty acid-based probes with high peroxisome specificity and bright fluorescence in the red/far-red spectrum, which makes them ideal to study peroxisomes in live cells and whole organisms.
Frustrated magnetic systems typically have multiple ground state configurations. While such multistability is common in amorphous materials, periodic mechanical systems have long range elastic interactions that tend to lead to a long-range ordered ground state. Herein, Sirote-Katz, Shohat et al. introduce periodic mechanical systems that have many disordered metastable states.
Copper isotopes in rifted alkaline rocks indicate that since the Neoproterozoic, cratonic mantle roots have been oxidized from metal-saturated environments with volatile CH4 and H2O to environments of stabilized CO2 and H2O and destabilized metals.
In this study, a deep learning-based model of left atrial size in UK Biobank enabled genome-wide association studies in 35,049 healthy participants. Several lines of evidence, including the PITX2 locus, linked left atrial dysfunction to atrial fibrillation risk.
How the hippocampus selects relevant events that are worth remembering is debated. Here, authors show midbrain dopamine neurons projecting to the hippocampus provide a teaching signal triggering NeoHebbian LTP and contextual learning.
Whether decisions are made in a graded or all-or-none fashion remains unclear. Here, the authors provide evidence to suggest that decisions conclude in a graded, rather than a binary, manner, thus providing an analog framework for flexible choice behavior.
The advancement of sodium halide solid-state electrolytes can propel high-energy-density all-solid-state sodium-ion batteries. Here, the authors present a LaCl3-based electrolyte facilitating rapid Na+ ion conduction along the c-axis diffusion channel, ensuring high capacity even at elevated current densities.
The brain networks orchestrating conscious recognition of auditory sequences are not well understood. Here, the authors reveal hierarchical processing from auditory cortices to hippocampus and cingulate gyrus, enhancing our understanding of predictive coding in memory.
Here the authors isolate monoclonal antibody HmAb64 from a healthy volunteer who received an experimental polyvalent DNA prime-protein boost HIV vaccine, and show that it’s specific for the CD4 binding site and neutralizes cross-subtype HIV isolates including several tier-2 viruses.
Tang et al. describe the development of a fungal genome mining tool which can be used to identify biosynthetic gene clusters from fungal genomes that lack detectable protein domains and demonstrate its functionality.
OsMAPK6 and CLG1, respectively, target GW6a for phosphorylation and ubiquitylation to favor the substrate stabilization using a different mechanism from prior reports, and the corresponding genetic axes operate non-additively to regulate seed size.
Trace amounts of strong acid can suppress Zn corrosion and promote uniform Zn deposition. Here, the authors use HTFSI to create a hydrophobic micro-environment at the Zn-electrolyte interface, enabling high efficiency and cycling stability.
The first three-dimensional spatial analysis of global marine conservation achievements and fisheries footprint reveals 3D conservation gaps and an underrepresentation of high protection levels across all depths while the 3D footprint of fisheries covers all depths.
In open-field-line magnetic plasma traps, the attainable cross-field voltage drops are limited by the tolerances of the solid materials of the vacuum vessel. Here, the authors demonstrate the possibility of equilibria that isolate large voltage drops to the interior of the plasma, circumventing this limit.
Natural materials exhibit compelling functionalities owing to their irregular architectures, but the study on irregular architected materials is elusive. Here the authors report a generative computational framework to virtually grow irregular materials with optimized properties that match target stress distributions, facilitating tissue support for orthopedic femur restoration.
It is challenging to design tough structures based on energy absorbing efficiency owing to the difficulties in modeling non-linear deformation. Here, the authors report a human-monitored self-driving lab and discover structural motifs with high energy absorbing efficiencies up to 75.2%.
Oligoclonal mixtures of neutralising antibodies can target multiple antigen components and represent a potential therapeutic solution for the treatment of envenomation. Here, the authors generate mixtures of nanobodies against coral snake venom toxins and demonstrate they can prevent lethality of coral snake venoms in pre-clinical animal models.
How the cortex forms spatially structured modules during development is poorly understood. Here, the authors show that activity in early developing cortex is self-organized though local-excitation and lateral inhibition.
Here, authors classify genes flanking the Heliorhodopsin (HeR)-encoding genes and identify highly conserved residues for protein–protein interactions, revealing a function of HeR as regulatory rhodopsin for multidrug resistance.